Epidemiology of hepatitis C virus infection & liver disease among injection drug users (IDUS) in Chennai, India

Shruti Hemendra Mehta, Samantha L. Vogt, Aylur K. Srikrishnan, Conjeevaram K. Vasudevan, Kalilapuri G. Murugavel, Shanmugam Saravanan, Santhanam Anand, M. Suresh Kumar, Stuart Campbell Ray, David D Celentano, Suniti Solomon, Sunil Solomon

Research output: Contribution to journalArticle

Abstract

Background & objectives: We characterized HCV antibody prevalence, viral persistence, genotype and liver disease prevalence among IDUs in Chennai, India as the study of the association of HIV with each of these states is important and there are no data available. Methods: Between 2005-2006, 1158 IDUs were recruited and followed semi-annually. All were tested for HCV antibodies at baseline; a random sample of 400 antibody positives (200 HIV-positive and 200 HIV-negative) were tested for HCV RNA; 13 of these were sequenced. Assessment of asparate amino transferase (AST)-to-platelet ratio index (APRI) was done on 557 IDUs. Prevalence ratios of each outcome were examined. Results: Median age was 35 yr; 99 per cent were male. HCV antibody prevalence was 55 per cent and was associated with older age, being unmarried, longer injection history, tattoo and injecting at a dealer's place. Of the 400 HCV antibody positive IDUs, 281 (70.3%) had persistent infection which was less common among hepatitis B-infected persons but not associated with HIV. Of the 13 samples sequenced, 11 (85%) were HCV genotype 3a. Fibrosis prevalence according to APRI was: HIV/HCV-uninfected, 4 per cent; HIV mono-infected, 3 per cent; HCV mono-infected, 11 per cent; HIV/HCV co-infected, 12 per cent (P

Original languageEnglish (US)
Pages (from-to)706-714
Number of pages9
JournalIndian Journal of Medical Research
Volume132
Issue number12
StatePublished - Dec 2010

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Epidemiology
Hepatitis C Antibodies
Virus Diseases
Drug Users
Viruses
Hepacivirus
Liver
Liver Diseases
India
HIV
Injections
Platelets
Pharmaceutical Preparations
Transferases
Blood Platelets
Genotype
RNA
Antibodies
Hepatitis B
Fibrosis

Keywords

  • APRI
  • HCV genotype
  • Hepatitis C virus
  • HIV
  • Injection drug users
  • Liver disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Epidemiology of hepatitis C virus infection & liver disease among injection drug users (IDUS) in Chennai, India. / Mehta, Shruti Hemendra; Vogt, Samantha L.; Srikrishnan, Aylur K.; Vasudevan, Conjeevaram K.; Murugavel, Kalilapuri G.; Saravanan, Shanmugam; Anand, Santhanam; Suresh Kumar, M.; Ray, Stuart Campbell; Celentano, David D; Solomon, Suniti; Solomon, Sunil.

In: Indian Journal of Medical Research, Vol. 132, No. 12, 12.2010, p. 706-714.

Research output: Contribution to journalArticle

Mehta, SH, Vogt, SL, Srikrishnan, AK, Vasudevan, CK, Murugavel, KG, Saravanan, S, Anand, S, Suresh Kumar, M, Ray, SC, Celentano, DD, Solomon, S & Solomon, S 2010, 'Epidemiology of hepatitis C virus infection & liver disease among injection drug users (IDUS) in Chennai, India', Indian Journal of Medical Research, vol. 132, no. 12, pp. 706-714.
Mehta SH, Vogt SL, Srikrishnan AK, Vasudevan CK, Murugavel KG, Saravanan S et al. Epidemiology of hepatitis C virus infection & liver disease among injection drug users (IDUS) in Chennai, India. Indian Journal of Medical Research. 2010 Dec;132(12):706-714.
Mehta, Shruti Hemendra ; Vogt, Samantha L. ; Srikrishnan, Aylur K. ; Vasudevan, Conjeevaram K. ; Murugavel, Kalilapuri G. ; Saravanan, Shanmugam ; Anand, Santhanam ; Suresh Kumar, M. ; Ray, Stuart Campbell ; Celentano, David D ; Solomon, Suniti ; Solomon, Sunil. / Epidemiology of hepatitis C virus infection & liver disease among injection drug users (IDUS) in Chennai, India. In: Indian Journal of Medical Research. 2010 ; Vol. 132, No. 12. pp. 706-714.
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