Epidemiology of head and neck squamous cell cancer among HIV-infected patients

Gypsyamber D'Souza, Thomas E. Carey, William N. William, Minh Ly Nguyen, Eric C. Ko, James Riddell, Sara Isabel Pai, Vishal Gupta, Heather M. Walline, J. Jack Lee, Gregory T. Wolf, Dong M. Shin, Jennifer R. Grandis, Robert L. Ferris

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43 Scopus citations


Background: HIV-infected individuals have a higher incidence of head and neck cancer (HNC). Methods: Case series of 94 HIV-infected HNC patients (HIVHNC) at 6 tertiary care referral centers in the US between 1991 and 2011. Clinical and risk factor data were abstracted from the medical record. Risk factors for survival were analyzed using Cox proportional hazard models. Human papillomavirus (HPV) and p16 testing was performed in 46 tumors. Findings were compared with Surveillance Epidemiology and End Results HNC (US-HNC) data. Results: This study represents the largest HIV-HNC series reported to date. HIV-HNC cases were more likely than US-HNC to be male (91% vs. 68%), younger (median age, 50 vs. 62 years), nonwhite (49% vs. 18%), and current smokers (61% vs. 18%). Median HIVHNC survival was not appreciably lower than US-HNC survival (63 vs. 61 months). At diagnosis, most cases were currently on highly active antiretroviral therapy (77%) but had detectable HIV viremia (99%), and median CD4 was 300 cells per microliter (interquartile range = 167-500). HPV was detected in 30% of HIV-HNC and 64% of HIV-oropharyngeal cases. Median survival was significantly lower among those with CD4 counts ≤200 than >200 cells per microliter at diagnosis (16.1 vs. 72.8 months, P > 0.001). In multivariate analysis, poorer survival was associated with CD4 >100 cells per microliter [adjusted hazard ratio (aHR) = 3.09, 95% confidence interval (CI): 1.15 to 8.30], larynx/hypopharynx site (aHR = 3.54, 95% CI: 1.34 to 9.35), and current tobacco use (aHR = 2.54, 95% CI: 0.96 to 6.76). Conclusions: Risk factors for the development of HNC in patients with HIV infection are similar to the general population, including both HPV-related and tobacco/alcohol-related HNC.

Original languageEnglish (US)
Pages (from-to)603-610
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number5
StatePublished - Apr 15 2014


  • Case series
  • Epidemiology
  • HIV
  • HNC
  • HPV
  • Immunosuppression
  • Survival

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)


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