Epidemiology of coagulation factors, inhibitors and activation markers: The Third Glasgow MONICA Survey I. Illustrative reference ranges by age, sex and hormone use

G. D.O. Lowe, A. Rumley, M. Woodward, C. E. Morrison, H. Philippou, D. A. Lane, H. Tunstall-Pedoe

Research output: Contribution to journalArticle

Abstract

Coagulation factor activity (fibrinogen, VII, VIII and IX), coagulation inhibitor activity (antithrombin, protein C, protein S), and coagulation activation markers (prothrombin fragment F1, 2; thrombin-antithrombin complexes) were measured in 747 men and 817 women aged 25-74 years, randomly sampled from the north Glasgow populaton in the Third MONICA Survey. Significant effects of age, sex, menopause and hormone use were observed and specific reference ranges are presented to illustrate these effects. Significant correlations were observed between several coagulation factors and inhibitors. Increased levels of factors VII, VIII and IX and decreased levels of protein C were associated with increased coagulation activation. In general, increases in coagulation factors with age were greater than increases in coagulation inhibitors, especially in men; this imbalance may favour increased coagulation activation and hence increased thrombotic risk with age.

Original languageEnglish (US)
Pages (from-to)775-784
Number of pages10
JournalBritish journal of haematology
Volume97
Issue number4
DOIs
StatePublished - Jan 1 1997

Keywords

  • Cardiovascular disease
  • Coagulation factors
  • Coagulation inhibitors
  • Thrombosis

ASJC Scopus subject areas

  • Hematology

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