TY - JOUR
T1 - Epidemiology of cat-scratch disease hospitalisations among children in the United States
AU - Reynolds, Mary G.
AU - Holman, Robert C.
AU - Curns, Aaron T.
AU - O'Reilly, Michael
AU - McQuiston, Jennifer H.
AU - Steiner, Claudia A.
N1 - Funding Information:
We thank the state data organizations that participated in the HCUP Kids' Inpatient Database (KID) 2000: Arizona Department of Health Services; California Office of Statewide Health Planning and Development; Colorado Health and Hospital Association; Connecticut–CHIME, Inc.; Florida Agency for Health Care Administration; Georgia GHA: An Association of Hospitals and Health Systems; Hawaii Health Information Corporation; Illinois Health Care Cost Containment Council; Iowa Hospital Association; Kansas Hospital Association; Kentucky Department for Public Health; Maine Health Data Organization; Maryland Health Services Cost Review Commission; Massachusetts Division of Health Care Finance and Policy; Missouri Hospital Industry Data Institute; New Jersey Department of Health and Senior Services; New York State Department of Health; North Carolina Department of Health and Human Services; Oregon Association of Hospitals and Health Systems; Pennsylvania Health Care Cost Containment Council; South Carolina State Budget and Control Board; Tennessee Hospital Association; Texas Health Care Information Council; Utah Department of Health; Virginia Health Information; Washington State Department of Health; West Virginia Health Care Authority; Wisconsin Department of Health and Family Services.
PY - 2005/8
Y1 - 2005/8
N2 - Background: Cat-scratch disease (CSD), caused by infection with Bartonella henselae, affects both children and adults but is principally a pediatric disease. Typical CSD is generally benign and self-limited and is characterized by regional lymphadenopathy with fever. Infections can, however, be accompanied by focal or diffuse inflammatory responses (atypical CSD) involving neurologic, organ (liver/spleen), lymphatic or skeletal systems. Methods: Pediatric hospitalizations with CSD listed as a diagnosis were examined using the Kids' Inpatient Database for the year 2000. National estimates of CSD-associated hospitalizations, hospitalization rates and various hospitalization statistics were examined for patients younger than 18 years of age. Results: During 2000, an estimated 437 (SE 43) pediatric hospitalizations associated with CSD occurred among children younger than 18 years of age in the United States. The national CSD-associated hospitalization rate was 0.60/100,000 children younger than 18 years of age (95% confidence interval, 0.49-0.72) and 0.86/100,000 children younger than 5 years of age (95% CI 0.64-1.07). Accompanying diagnoses included neurologic complications (12%), organ (liver/spleen) involvement (7%) and "other" (5%). Atypical CSD accounted for ∼24% of the CSD-associated hospitalizations. The median charge for a CSD-associated hospitalization was $6140 with total annual hospital charges of ∼$3.5 million among children in the United States. Conclusions: The CSD-associated hospitalization rate among children during 2000 appeared similar to those estimated for the 1980s in the United States, despite significant increases in cat ownership in the intervening time. Early serologic and molecular testing for CSD in children is suggested to minimize unnecessary interventions and promote optimally effective care when supportive measures are required.
AB - Background: Cat-scratch disease (CSD), caused by infection with Bartonella henselae, affects both children and adults but is principally a pediatric disease. Typical CSD is generally benign and self-limited and is characterized by regional lymphadenopathy with fever. Infections can, however, be accompanied by focal or diffuse inflammatory responses (atypical CSD) involving neurologic, organ (liver/spleen), lymphatic or skeletal systems. Methods: Pediatric hospitalizations with CSD listed as a diagnosis were examined using the Kids' Inpatient Database for the year 2000. National estimates of CSD-associated hospitalizations, hospitalization rates and various hospitalization statistics were examined for patients younger than 18 years of age. Results: During 2000, an estimated 437 (SE 43) pediatric hospitalizations associated with CSD occurred among children younger than 18 years of age in the United States. The national CSD-associated hospitalization rate was 0.60/100,000 children younger than 18 years of age (95% confidence interval, 0.49-0.72) and 0.86/100,000 children younger than 5 years of age (95% CI 0.64-1.07). Accompanying diagnoses included neurologic complications (12%), organ (liver/spleen) involvement (7%) and "other" (5%). Atypical CSD accounted for ∼24% of the CSD-associated hospitalizations. The median charge for a CSD-associated hospitalization was $6140 with total annual hospital charges of ∼$3.5 million among children in the United States. Conclusions: The CSD-associated hospitalization rate among children during 2000 appeared similar to those estimated for the 1980s in the United States, despite significant increases in cat ownership in the intervening time. Early serologic and molecular testing for CSD in children is suggested to minimize unnecessary interventions and promote optimally effective care when supportive measures are required.
KW - Bartonella
KW - Cat-scratch disease
KW - Epidemiology
KW - Healthcare cost and utilization project
KW - Hospitalization
UR - http://www.scopus.com/inward/record.url?scp=23744448018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23744448018&partnerID=8YFLogxK
U2 - 10.1097/01.inf.0000172185.01939.fc
DO - 10.1097/01.inf.0000172185.01939.fc
M3 - Article
C2 - 16094224
AN - SCOPUS:23744448018
SN - 0891-3668
VL - 24
SP - 700
EP - 704
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
IS - 8
ER -