Epidemiology, diagnosis, and treatment of Hymenoptera venom allergy in mastocytosis patients

Marek Niedoszytko, Patrizia Bonadonna, Joanne N.G.Oude Elberink, David B.K. Golden

Research output: Contribution to journalReview article

Abstract

Hymenoptera venom allergy is a typical IgE-mediated reaction caused by sensitization to 1 or more allergens of the venom, and accounts for 1.5% to 34% of all cases of anaphylaxis. Patients suffering from mastocytosis are more susceptible to the anaphylactic reactions to an insect sting. This article aims to answer the most important clinical questions raised by the diagnosis and treatment of insect venom allergy in mastocytosis patients. Total avoidance of Hymenoptera is not feasible, and there is no preventive pharmacologic treatment available, although venom immunotherapy reduces the risk of subsequent systemic reactions.

Original languageEnglish (US)
Pages (from-to)365-381
Number of pages17
JournalImmunology and Allergy Clinics of North America
Volume34
Issue number2
DOIs
StatePublished - May 2014

Keywords

  • Hymenoptera venom allergy
  • Immunoglobulin E serology
  • Mastocytosis
  • Venom immunotherapy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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