Epidemiology and treatment of Cyclospora cayetanensis infection in Peruvian children

Guillermo Madico, Jeffrey McDonald, Robert H Gilman, Lilia Cabrera, Charles R. Sterling

Research output: Contribution to journalArticle

Abstract

Cyclospora cayetanensis was detected in fecal specimens from 63 (1.1%) of 5,836 Peruvian children studied over 2 years; the protozoan was detected by modified acid-fast staining and autofluorescence under ultraviolet light. The highest prevalence occurred among children between 2 and 4 years of age. Thirty-two percent (20) of the 63 C. cayetanensis-infected children were symptomatic. Nineteen infected children were enrolled in a double-blind, placebo-controlled trial of a 3-day course of trimethoprim-sulfamethoxazole (TMP-SMZ; 5/25 mg/[kg·d]). Children were followed up with daily stool examinations (mean number of samples examined per child ± SE, 19 ± 4). The mean duration of oocyst excretion ± SE was 4.8 ± 1.2 days for TMP-SMZ recipients compared with 12.1 ± 6.1 days for placebo recipients (P <.02). The prevalence of C. cayetanensis infection decreases during winter months and as children age; it decreases precipitously by adulthood. In children in areas of endemicity, C. cayetanensis usually causes mild disease that is often asymptomatic. TMP-SMZ therapy significantly decreases the duration of oocyst excretion.

Original languageEnglish (US)
Pages (from-to)977-981
Number of pages5
JournalClinical Infectious Diseases
Volume24
Issue number5
StatePublished - 1997

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Cyclospora
Epidemiology
Thymidine Monophosphate
Infection
Oocysts
Therapeutics
Placebos
Sulfamethoxazole Drug Combination Trimethoprim
Ultraviolet Rays
Staining and Labeling

ASJC Scopus subject areas

  • Immunology

Cite this

Madico, G., McDonald, J., Gilman, R. H., Cabrera, L., & Sterling, C. R. (1997). Epidemiology and treatment of Cyclospora cayetanensis infection in Peruvian children. Clinical Infectious Diseases, 24(5), 977-981.

Epidemiology and treatment of Cyclospora cayetanensis infection in Peruvian children. / Madico, Guillermo; McDonald, Jeffrey; Gilman, Robert H; Cabrera, Lilia; Sterling, Charles R.

In: Clinical Infectious Diseases, Vol. 24, No. 5, 1997, p. 977-981.

Research output: Contribution to journalArticle

Madico, G, McDonald, J, Gilman, RH, Cabrera, L & Sterling, CR 1997, 'Epidemiology and treatment of Cyclospora cayetanensis infection in Peruvian children', Clinical Infectious Diseases, vol. 24, no. 5, pp. 977-981.
Madico, Guillermo ; McDonald, Jeffrey ; Gilman, Robert H ; Cabrera, Lilia ; Sterling, Charles R. / Epidemiology and treatment of Cyclospora cayetanensis infection in Peruvian children. In: Clinical Infectious Diseases. 1997 ; Vol. 24, No. 5. pp. 977-981.
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