Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries

Brooks W. Morgan, Matthew R. Grigsby, Trishul Siddharthan, Muhammad Chowdhury, Adolfo Rubinstein, Laura Gutierrez, Vilma Irazola, J. Jaime Miranda, Antonio Bernabe-Ortiz, Dewan Alam, Robert A Wise, William Checkley

Research output: Contribution to journalArticle

Abstract

Background: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents the confluence of bronchial airway hyperreactivity and chronic airflow limitation and has been described as leading to worse lung function and quality of life than found with either singular disease process. Objective: We aimed to describe the prevalence and risk factors for ACO among adults across 6 low- and middle-income countries (LMICs). Methods: We compiled cross-sectional data for 11,923 participants aged 35 to 92 years from 4 population-based studies in 12 settings. We defined COPD as postbronchodilator FEV1/forced vital capacity ratio below the lower limit of normal, asthma as wheeze or medication use in 12 months or self-reported physician diagnosis, and ACO as having both. Results: The prevalence of ACO was 3.8% (0% in rural Puno, Peru, to 7.8% in Matlab, Bangladesh). The odds of having ACO were higher with household exposure to biomass fuel smoke (odds ratio [OR], 1.48; 95% CI, 0.98-2.23), smoking tobacco (OR, 1.28 per 10 pack-years; 95% CI, 1.22-1.34), and having primary or less education (OR, 1.35; 95% CI, 1.07-1.70) as compared to nonobstructed nonasthma individuals. ACO was associated with severe obstruction (FEV1 %, <50; 31.6% of ACO vs 10.9% of COPD alone) and severe spirometric deficits compared with participants with asthma (−1.61 z scores FEV1; 95% CI, −1.48 to −1.75) or COPD alone (−0.94 z scores; 95% CI, −0.78 to −1.10). Conclusions: ACO may be as prevalent and more severe in LMICs than has been reported in high-income settings. Exposure to biomass fuel smoke may be an overlooked risk factor, and we favor diagnostic criteria for ACO that include environmental exposures common to LMICs.

Original languageEnglish (US)
JournalJournal of Allergy and Clinical Immunology
DOIs
StateAccepted/In press - Jan 1 2018

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Chronic Obstructive Pulmonary Disease
Epidemiology
Asthma
Odds Ratio
Smoke
Biomass
Bronchial Hyperreactivity
Peru
Bangladesh
Vital Capacity
Environmental Exposure
Smoking
Quality of Life
Physicians
Education
Lung
Population

Keywords

  • ACO
  • Asthma
  • asthma-COPD overlap
  • chronic obstructive pulmonary disease
  • COPD
  • epidemiology
  • health outcomes
  • overlap
  • population-based
  • risk factors
  • spirometry

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries. / Morgan, Brooks W.; Grigsby, Matthew R.; Siddharthan, Trishul; Chowdhury, Muhammad; Rubinstein, Adolfo; Gutierrez, Laura; Irazola, Vilma; Miranda, J. Jaime; Bernabe-Ortiz, Antonio; Alam, Dewan; Wise, Robert A; Checkley, William.

In: Journal of Allergy and Clinical Immunology, 01.01.2018.

Research output: Contribution to journalArticle

Morgan, Brooks W. ; Grigsby, Matthew R. ; Siddharthan, Trishul ; Chowdhury, Muhammad ; Rubinstein, Adolfo ; Gutierrez, Laura ; Irazola, Vilma ; Miranda, J. Jaime ; Bernabe-Ortiz, Antonio ; Alam, Dewan ; Wise, Robert A ; Checkley, William. / Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries. In: Journal of Allergy and Clinical Immunology. 2018.
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AU - Grigsby, Matthew R.

AU - Siddharthan, Trishul

AU - Chowdhury, Muhammad

AU - Rubinstein, Adolfo

AU - Gutierrez, Laura

AU - Irazola, Vilma

AU - Miranda, J. Jaime

AU - Bernabe-Ortiz, Antonio

AU - Alam, Dewan

AU - Wise, Robert A

AU - Checkley, William

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N2 - Background: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents the confluence of bronchial airway hyperreactivity and chronic airflow limitation and has been described as leading to worse lung function and quality of life than found with either singular disease process. Objective: We aimed to describe the prevalence and risk factors for ACO among adults across 6 low- and middle-income countries (LMICs). Methods: We compiled cross-sectional data for 11,923 participants aged 35 to 92 years from 4 population-based studies in 12 settings. We defined COPD as postbronchodilator FEV1/forced vital capacity ratio below the lower limit of normal, asthma as wheeze or medication use in 12 months or self-reported physician diagnosis, and ACO as having both. Results: The prevalence of ACO was 3.8% (0% in rural Puno, Peru, to 7.8% in Matlab, Bangladesh). The odds of having ACO were higher with household exposure to biomass fuel smoke (odds ratio [OR], 1.48; 95% CI, 0.98-2.23), smoking tobacco (OR, 1.28 per 10 pack-years; 95% CI, 1.22-1.34), and having primary or less education (OR, 1.35; 95% CI, 1.07-1.70) as compared to nonobstructed nonasthma individuals. ACO was associated with severe obstruction (FEV1 %, <50; 31.6% of ACO vs 10.9% of COPD alone) and severe spirometric deficits compared with participants with asthma (−1.61 z scores FEV1; 95% CI, −1.48 to −1.75) or COPD alone (−0.94 z scores; 95% CI, −0.78 to −1.10). Conclusions: ACO may be as prevalent and more severe in LMICs than has been reported in high-income settings. Exposure to biomass fuel smoke may be an overlooked risk factor, and we favor diagnostic criteria for ACO that include environmental exposures common to LMICs.

AB - Background: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents the confluence of bronchial airway hyperreactivity and chronic airflow limitation and has been described as leading to worse lung function and quality of life than found with either singular disease process. Objective: We aimed to describe the prevalence and risk factors for ACO among adults across 6 low- and middle-income countries (LMICs). Methods: We compiled cross-sectional data for 11,923 participants aged 35 to 92 years from 4 population-based studies in 12 settings. We defined COPD as postbronchodilator FEV1/forced vital capacity ratio below the lower limit of normal, asthma as wheeze or medication use in 12 months or self-reported physician diagnosis, and ACO as having both. Results: The prevalence of ACO was 3.8% (0% in rural Puno, Peru, to 7.8% in Matlab, Bangladesh). The odds of having ACO were higher with household exposure to biomass fuel smoke (odds ratio [OR], 1.48; 95% CI, 0.98-2.23), smoking tobacco (OR, 1.28 per 10 pack-years; 95% CI, 1.22-1.34), and having primary or less education (OR, 1.35; 95% CI, 1.07-1.70) as compared to nonobstructed nonasthma individuals. ACO was associated with severe obstruction (FEV1 %, <50; 31.6% of ACO vs 10.9% of COPD alone) and severe spirometric deficits compared with participants with asthma (−1.61 z scores FEV1; 95% CI, −1.48 to −1.75) or COPD alone (−0.94 z scores; 95% CI, −0.78 to −1.10). Conclusions: ACO may be as prevalent and more severe in LMICs than has been reported in high-income settings. Exposure to biomass fuel smoke may be an overlooked risk factor, and we favor diagnostic criteria for ACO that include environmental exposures common to LMICs.

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