Epidemiology and risk factors for alcoholic liver disease

Mariana Lazo-Elizondo, Mack C. Mitchell

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Development of liver damage and cirrhosis (ALD) related to alcohol consumption is complex. Studies have reported a threshold of drinking 20-30 g daily for women compared to 40-50 g daily for men. However, the absolute risk of ALD related to heavy drinking is relatively low, ranging from 6 to 15 %, so the majority of drinkers do not develop significant damage. Consuming more than 50 g of alcohol daily can accelerate progression of chronic hepatitis C and genetic hemochromatosis. Prior studies eliminated generalized malnutrition, chronic hepatitis B infection, and the type of alcoholic beverage consumed as risk factors. Obesity is an important risk factor for ALD in heavy drinkers and substantial evidence suggests genetic risks for liver damage in heavy drinkers as well as a genetic risk for drinking heavily (alcohol use disorders). A single-nucleotide polymorphism in PNPLA3 (G allele) is the most important genetic factor associated with an increase in the risk of alcoholic cirrhosis. Risk factors for obesity are also genetically determined, leading to a complex model for understanding the risk of developing ALD. Individual risk factors for ALD are potentially quantifiable within a population and will identify those populations at higher or lower risk for disease related to alcohol consumption. Careful studies of the patterns and levels of consumption of alcoholic beverages in genetically well-characterized populations are needed to understand the complex interaction between genes and the environment in the development of liver injury due to alcohol. Once these results are obtained, sound advice about the risk associated with consumption of alcoholic beverages can be provided to individuals.

Original languageEnglish (US)
Title of host publicationAlcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside
PublisherSpringer International Publishing
Pages1-20
Number of pages20
ISBN (Electronic)9783319205380
ISBN (Print)9783319205373
DOIs
StatePublished - Jan 1 2015

Fingerprint

Alcoholic Liver Diseases
Epidemiology
Alcoholic Beverages
Alcohol Drinking
Drinking
Obesity
Alcohols
Population
Alcoholic Liver Cirrhosis
Gene-Environment Interaction
Hemochromatosis
Liver
Chronic Hepatitis B
Chronic Hepatitis C
Malnutrition
Liver Cirrhosis
Single Nucleotide Polymorphism
Alleles
Wounds and Injuries
Infection

Keywords

  • Alcoholic cirrhosis
  • Case-control studies
  • Chronic hepatitis C
  • Epidemiology
  • Hemochromatosis
  • Obesity
  • PNPLA3 (adiponutrin)
  • Population studies
  • Risk factors

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lazo-Elizondo, M., & Mitchell, M. C. (2015). Epidemiology and risk factors for alcoholic liver disease. In Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside (pp. 1-20). Springer International Publishing. https://doi.org/10.1007/978-3-319-20538-0_1

Epidemiology and risk factors for alcoholic liver disease. / Lazo-Elizondo, Mariana; Mitchell, Mack C.

Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside. Springer International Publishing, 2015. p. 1-20.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lazo-Elizondo, M & Mitchell, MC 2015, Epidemiology and risk factors for alcoholic liver disease. in Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside. Springer International Publishing, pp. 1-20. https://doi.org/10.1007/978-3-319-20538-0_1
Lazo-Elizondo M, Mitchell MC. Epidemiology and risk factors for alcoholic liver disease. In Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside. Springer International Publishing. 2015. p. 1-20 https://doi.org/10.1007/978-3-319-20538-0_1
Lazo-Elizondo, Mariana ; Mitchell, Mack C. / Epidemiology and risk factors for alcoholic liver disease. Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside. Springer International Publishing, 2015. pp. 1-20
@inbook{e76a1af06e1f4856b89abfb032535877,
title = "Epidemiology and risk factors for alcoholic liver disease",
abstract = "Development of liver damage and cirrhosis (ALD) related to alcohol consumption is complex. Studies have reported a threshold of drinking 20-30 g daily for women compared to 40-50 g daily for men. However, the absolute risk of ALD related to heavy drinking is relatively low, ranging from 6 to 15 {\%}, so the majority of drinkers do not develop significant damage. Consuming more than 50 g of alcohol daily can accelerate progression of chronic hepatitis C and genetic hemochromatosis. Prior studies eliminated generalized malnutrition, chronic hepatitis B infection, and the type of alcoholic beverage consumed as risk factors. Obesity is an important risk factor for ALD in heavy drinkers and substantial evidence suggests genetic risks for liver damage in heavy drinkers as well as a genetic risk for drinking heavily (alcohol use disorders). A single-nucleotide polymorphism in PNPLA3 (G allele) is the most important genetic factor associated with an increase in the risk of alcoholic cirrhosis. Risk factors for obesity are also genetically determined, leading to a complex model for understanding the risk of developing ALD. Individual risk factors for ALD are potentially quantifiable within a population and will identify those populations at higher or lower risk for disease related to alcohol consumption. Careful studies of the patterns and levels of consumption of alcoholic beverages in genetically well-characterized populations are needed to understand the complex interaction between genes and the environment in the development of liver injury due to alcohol. Once these results are obtained, sound advice about the risk associated with consumption of alcoholic beverages can be provided to individuals.",
keywords = "Alcoholic cirrhosis, Case-control studies, Chronic hepatitis C, Epidemiology, Hemochromatosis, Obesity, PNPLA3 (adiponutrin), Population studies, Risk factors",
author = "Mariana Lazo-Elizondo and Mitchell, {Mack C.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1007/978-3-319-20538-0_1",
language = "English (US)",
isbn = "9783319205373",
pages = "1--20",
booktitle = "Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside",
publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Epidemiology and risk factors for alcoholic liver disease

AU - Lazo-Elizondo, Mariana

AU - Mitchell, Mack C.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Development of liver damage and cirrhosis (ALD) related to alcohol consumption is complex. Studies have reported a threshold of drinking 20-30 g daily for women compared to 40-50 g daily for men. However, the absolute risk of ALD related to heavy drinking is relatively low, ranging from 6 to 15 %, so the majority of drinkers do not develop significant damage. Consuming more than 50 g of alcohol daily can accelerate progression of chronic hepatitis C and genetic hemochromatosis. Prior studies eliminated generalized malnutrition, chronic hepatitis B infection, and the type of alcoholic beverage consumed as risk factors. Obesity is an important risk factor for ALD in heavy drinkers and substantial evidence suggests genetic risks for liver damage in heavy drinkers as well as a genetic risk for drinking heavily (alcohol use disorders). A single-nucleotide polymorphism in PNPLA3 (G allele) is the most important genetic factor associated with an increase in the risk of alcoholic cirrhosis. Risk factors for obesity are also genetically determined, leading to a complex model for understanding the risk of developing ALD. Individual risk factors for ALD are potentially quantifiable within a population and will identify those populations at higher or lower risk for disease related to alcohol consumption. Careful studies of the patterns and levels of consumption of alcoholic beverages in genetically well-characterized populations are needed to understand the complex interaction between genes and the environment in the development of liver injury due to alcohol. Once these results are obtained, sound advice about the risk associated with consumption of alcoholic beverages can be provided to individuals.

AB - Development of liver damage and cirrhosis (ALD) related to alcohol consumption is complex. Studies have reported a threshold of drinking 20-30 g daily for women compared to 40-50 g daily for men. However, the absolute risk of ALD related to heavy drinking is relatively low, ranging from 6 to 15 %, so the majority of drinkers do not develop significant damage. Consuming more than 50 g of alcohol daily can accelerate progression of chronic hepatitis C and genetic hemochromatosis. Prior studies eliminated generalized malnutrition, chronic hepatitis B infection, and the type of alcoholic beverage consumed as risk factors. Obesity is an important risk factor for ALD in heavy drinkers and substantial evidence suggests genetic risks for liver damage in heavy drinkers as well as a genetic risk for drinking heavily (alcohol use disorders). A single-nucleotide polymorphism in PNPLA3 (G allele) is the most important genetic factor associated with an increase in the risk of alcoholic cirrhosis. Risk factors for obesity are also genetically determined, leading to a complex model for understanding the risk of developing ALD. Individual risk factors for ALD are potentially quantifiable within a population and will identify those populations at higher or lower risk for disease related to alcohol consumption. Careful studies of the patterns and levels of consumption of alcoholic beverages in genetically well-characterized populations are needed to understand the complex interaction between genes and the environment in the development of liver injury due to alcohol. Once these results are obtained, sound advice about the risk associated with consumption of alcoholic beverages can be provided to individuals.

KW - Alcoholic cirrhosis

KW - Case-control studies

KW - Chronic hepatitis C

KW - Epidemiology

KW - Hemochromatosis

KW - Obesity

KW - PNPLA3 (adiponutrin)

KW - Population studies

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=85016744717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016744717&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-20538-0_1

DO - 10.1007/978-3-319-20538-0_1

M3 - Chapter

AN - SCOPUS:85016744717

SN - 9783319205373

SP - 1

EP - 20

BT - Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside

PB - Springer International Publishing

ER -