TY - JOUR
T1 - Epidemiology and outcomes of open globe injuries
T2 - the international globe and adnexal trauma epidemiology study (IGATES)
AU - IGATES Study Group - An Asia Pacific Ophthalmic Trauma Society publication
AU - Hoskin, Annette K.
AU - Low, Rebecca
AU - Sen, Parveen
AU - Mishra, Chitaranjan
AU - Kamalden, Tengku Ain
AU - Woreta, Fasika
AU - Shah, Mehul
AU - Pauly, Marian
AU - Rousselot, Andres
AU - Sundar, Gangadhara
AU - Natarajan, Sundaram
AU - Keay, Lisa
AU - Gunasekeran, Dinesh Visva
AU - Watson, Stephanie L.
AU - Agrawal, Rupesh
AU - Gooty, Satish
AU - Arjun,
AU - Pravallika,
AU - Tarannum,
AU - Kim, R.
AU - Chaudhary, Meenu
AU - Shah, Shreya Mehul
AU - Giridhar,
AU - Khaqan, Hussain
AU - Khatri, Anadi
AU - Jayadev, Chaitra
AU - Jain, Kushagra
AU - Kan, John
AU - Dinesh, Vg
AU - Chee, Caroline
AU - Koh, Victor
AU - Khandelwal, Rekha
AU - Sen, Alok
AU - Singh, Shakeen
AU - Awan, Amer
AU - Grover, Ashok
AU - Mittal, Anurag
AU - Hoskin, Annette
AU - Pradhan, Eli
AU - Addenan, Maftuhim
AU - Ch’ng, Hannie
AU - Zamawi, Fatin Nadia
N1 - Funding Information:
We thank Dr. Dhananjay Raje and Ms. Moumita Chakraborty, Data Analysis Group, MDS Bio-Analytics, Nagpur, India, for their assistance in clinical information analysis. Secure encrypted platform was programmed in Amazon Cognito® by D.V.G and R.A and maintained and stored on servers at the Tan Tock Seng Hospital, Singapore.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Purpose: To detail the methodology for a novel ocular trauma registry and utilize the registry to determine the demographics, nature of injury, and associations of severe visual loss for open globe injuries (OGI). Methods: Thirteen hospitals in 7 countries used International Globe and Adnexal Trauma Epidemiology Study (IGATES) platform. Patients presenting between April 2009 and 2020 with OGI (with or without) adnexal involvement or intraocular foreign body (IOFB) were included. Results: Analyses of presenting and final VA, using “severe vision loss” (VA ≤ 6/60) and “no severe loss” (VA > 6/60), were performed. Four hundred fifty-four (64%) patients had VA < 6/60 at presentation and 327 (44.8%) at final follow-up, with a highly significant association between presenting and final VA (p < 0.0001). From the cohort of 746 patients, 37 were missing VA at presentation and 16 at follow-up and complete clinical data was available for 354 patients. The male to female ratio is 6:1, and mean age 36.0 ± 20.0 years old. Relative afferent pupillary defect (RAPD), zone III injury, IOFB, and eyelid injury at presentation were recorded in 50 (6.7%), 55 (7.8%), 97 (13%), and 87 (11.7%) patients, respectively, and were significantly associated with VA < 6/60 at follow-up. Older age, ≥ 61 years, was associated with 3.39 times (95% CI: 1.95–5.89) higher risk than ≤20-year-old patients (p < 0.0001) and males 0.424 times (95% CI: 0.27–0.70) lower risk than female (p = 0.0001) of severe vision loss (SVL). Conclusion: In OGIs from 13 hospitals, female gender, older age, zone III injury, eyelid injury, and IOFB were associated with higher risk of visual outcome of SVL.
AB - Purpose: To detail the methodology for a novel ocular trauma registry and utilize the registry to determine the demographics, nature of injury, and associations of severe visual loss for open globe injuries (OGI). Methods: Thirteen hospitals in 7 countries used International Globe and Adnexal Trauma Epidemiology Study (IGATES) platform. Patients presenting between April 2009 and 2020 with OGI (with or without) adnexal involvement or intraocular foreign body (IOFB) were included. Results: Analyses of presenting and final VA, using “severe vision loss” (VA ≤ 6/60) and “no severe loss” (VA > 6/60), were performed. Four hundred fifty-four (64%) patients had VA < 6/60 at presentation and 327 (44.8%) at final follow-up, with a highly significant association between presenting and final VA (p < 0.0001). From the cohort of 746 patients, 37 were missing VA at presentation and 16 at follow-up and complete clinical data was available for 354 patients. The male to female ratio is 6:1, and mean age 36.0 ± 20.0 years old. Relative afferent pupillary defect (RAPD), zone III injury, IOFB, and eyelid injury at presentation were recorded in 50 (6.7%), 55 (7.8%), 97 (13%), and 87 (11.7%) patients, respectively, and were significantly associated with VA < 6/60 at follow-up. Older age, ≥ 61 years, was associated with 3.39 times (95% CI: 1.95–5.89) higher risk than ≤20-year-old patients (p < 0.0001) and males 0.424 times (95% CI: 0.27–0.70) lower risk than female (p = 0.0001) of severe vision loss (SVL). Conclusion: In OGIs from 13 hospitals, female gender, older age, zone III injury, eyelid injury, and IOFB were associated with higher risk of visual outcome of SVL.
KW - Ocular trauma
KW - Open globe injury
KW - Prevention
KW - Registry
KW - Vision loss
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U2 - 10.1007/s00417-021-05266-1
DO - 10.1007/s00417-021-05266-1
M3 - Article
C2 - 34173879
AN - SCOPUS:85108878166
SN - 0721-832X
VL - 259
SP - 3485
EP - 3499
JO - Graefe's Archive for Clinical and Experimental Ophthalmology
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
IS - 11
ER -