Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients

Kieren Marr, Rachel A. Carter, Fulvio Crippa, Anna Wald, Lawrence Corey

Research output: Contribution to journalArticle

Abstract

Reports have focused on the emergence of moulds as pathogens in recipients of hematopoietic stem cell transplants. To review the incidence of and risks for mould infections, we examined the records of 5589 patients who underwent hematopoietic stem cell transplantation at the Fred Hutchinson Cancer Research Center (Seattle) from 1985 through 1999. After 1992, the incidence of invasive aspergillosis increased in allograft recipients and remained high through the 1990s. Infections with non-fumigatus Aspergillus species, Fusarium species, and Zygomycetes increased during the late 1990s, especially in patients who received multiple transplants. Although infection caused by Scedosporium species was common in patients who had neutropenia, infection caused by Zygomycetes typically occurred later after transplantation, when patients had graft-versus-host disease. The overall 1-year survival rate was equally poor (∼20%) for all patients with mould infections. The results of the present study demonstrate the changing epidemiology of mould infections, emphasizing the increasing importance of amphotericin B-resistant organisms and the differences in risks and outcome of infection with different filamentous fungi.

Original languageEnglish (US)
Pages (from-to)909-917
Number of pages9
JournalClinical Infectious Diseases
Volume34
Issue number7
DOIs
StatePublished - Apr 1 2002
Externally publishedYes

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Hematopoietic Stem Cells
Epidemiology
Fungi
Transplants
Infection
Scedosporium
Aspergillosis
Hematopoietic Stem Cell Transplantation
Incidence
Fusarium
Amphotericin B
Graft vs Host Disease
Aspergillus
Transplant Recipients
Neutropenia
Allografts
Survival Rate
Transplantation
Research
Neoplasms

ASJC Scopus subject areas

  • Immunology

Cite this

Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients. / Marr, Kieren; Carter, Rachel A.; Crippa, Fulvio; Wald, Anna; Corey, Lawrence.

In: Clinical Infectious Diseases, Vol. 34, No. 7, 01.04.2002, p. 909-917.

Research output: Contribution to journalArticle

Marr, Kieren ; Carter, Rachel A. ; Crippa, Fulvio ; Wald, Anna ; Corey, Lawrence. / Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients. In: Clinical Infectious Diseases. 2002 ; Vol. 34, No. 7. pp. 909-917.
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