The prevalence of Mycoplasma pneumoniae among HIV-positive patients with community-acquired pneumonia (CAP) remains unclear. We investigated 300 HIV-positive adults (200 with CAP and 100 with no respiratory illness) and 75 HTV-negative adults with CAP for the prevalence of respiratory pathogens using culture and serology. A growth inhibition test was employed to confirm the isolates of M. pneumoniae using species-specific typing sera. The prevalence ofM. pneumoniae in HIV-positive subjects was 17% by induced sputum and 11.3% by throat swab culture. The seroprevalence of anti-M. pneumoniae IgM was 11.7% by ELISA and 14.3% by the gelatin microparticle agglutination test. The prevalence ofM. pneumoniae among HIV-negative cases was relatively low. Streptococcuspneumoniae was predominant (28%) among subjects with lower respiratory disease, whereas Staphylococcus aureus (15%) was common among upper respiratory symptomatic cases. Rales (P = 0.001), pharyngeal erythema (P = 0.02), cervical adenopathy (P = 0.004), skin rash (P = 0.001), and crepitations (P = 0.001) were each significantly related to M. pneumoniae positivity. Statistical significance was observed in relation to total lymphocyte count (P = 0.02) and erythrocyte sedimentation rate (P = 0.04), as well as to M.pneumoniae positivity. This study shows that the prevalence of M.pneumoniae in MV-positive subjects is comparatively higher than in HIV-negative subjects with pulmonary symptoms, and concords with previous pilot studies carried out in Chennai, South lndia.
|Original language||English (US)|
|Number of pages||5|
|Journal||Japanese Journal of Infectious Diseases|
|State||Published - Dec 4 2007|
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases