Epidemiological studies on pulmonary pathogens in HIV-positive and -negative subjects with or without community-acquired pneumonia with special emphasis on Mycoplasma pneumoniae

Esaki Muthu Shankar, Nagalingeswaran Kumarasamy, Ramachandran Vignesh, Pachamuthu Balakrishnan, Sunil Suhas Solomon, Kailapuri Gangatharan Murugavel, Shanmugam Saravanan, Vijayakumar Velu, Shukkur Muhammed Farooq, Kownhar Hayath, Sundaram Muthu+, Suniti Solomon, Usha Anand Rao

Research output: Contribution to journalArticlepeer-review

Abstract

The prevalence of Mycoplasma pneumoniae among HIV-positive patients with community-acquired pneumonia (CAP) remains unclear. We investigated 300 HIV-positive adults (200 with CAP and 100 with no respiratory illness) and 75 HTV-negative adults with CAP for the prevalence of respiratory pathogens using culture and serology. A growth inhibition test was employed to confirm the isolates of M. pneumoniae using species-specific typing sera. The prevalence ofM. pneumoniae in HIV-positive subjects was 17% by induced sputum and 11.3% by throat swab culture. The seroprevalence of anti-M. pneumoniae IgM was 11.7% by ELISA and 14.3% by the gelatin microparticle agglutination test. The prevalence ofM. pneumoniae among HIV-negative cases was relatively low. Streptococcuspneumoniae was predominant (28%) among subjects with lower respiratory disease, whereas Staphylococcus aureus (15%) was common among upper respiratory symptomatic cases. Rales (P = 0.001), pharyngeal erythema (P = 0.02), cervical adenopathy (P = 0.004), skin rash (P = 0.001), and crepitations (P = 0.001) were each significantly related to M. pneumoniae positivity. Statistical significance was observed in relation to total lymphocyte count (P = 0.02) and erythrocyte sedimentation rate (P = 0.04), as well as to M.pneumoniae positivity. This study shows that the prevalence of M.pneumoniae in MV-positive subjects is comparatively higher than in HIV-negative subjects with pulmonary symptoms, and concords with previous pilot studies carried out in Chennai, South lndia.

Original languageEnglish (US)
Pages (from-to)337-341
Number of pages5
JournalJapanese Journal of Infectious Diseases
Volume60
Issue number6
StatePublished - Dec 4 2007
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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