The Seven Countries Study, reported by Ancel Keys in 1970, was the first substantive epidemiological evidence to support the hypothesis that multiple dietary factors determine coronary heart disease (CHD) risk. This seminal longitudinal study of populations in Europe, Asia, and the United States was conducted with rigorous, standardized dietary data collection and meticulously tracked clinical outcomes. A striking finding was the apparent large CHD risk reduction associated with consumption of a Crete, a.k.a. Mediterranean diet. Since this report, further research has attempted to confirm these findings and characterize features of the diet which may account for the substantial reduction in CHD risk.
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