Epidemiological studies of the non-specific effects of vaccines: II - Methodological issues in the design and analysis of cohort studies

C. P. Farrington, M. J. Firth, L. H. Moulton, H. Ravn, P. K. Andersen, S. Evans

Research output: Contribution to journalReview articlepeer-review

Abstract

We review sources of bias which can affect non-randomized cohort studies of non-specific effects of vaccines on child mortality. Using examples from the literature on non-specific effects, we describe different sources of selection and information bias, and, where possible, outline analysis strategies to mitigate or eliminate such biases.

Original languageEnglish (US)
Pages (from-to)977-985
Number of pages9
JournalTropical Medicine and International Health
Volume14
Issue number9
DOIs
StatePublished - Sep 2009

Keywords

  • Methodology
  • Mortality
  • Non-specific effects
  • Vaccines

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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