Epidemiological assessment of Schistosoma haematobium-induced kidney and bladder pathology in rural Zimbabwe

Kimberly C. Brouwer, Patricia D. Ndhlovu, Yukiko Wagatsuma, Anderson Munatsi, Clive Julian Shiff

Research output: Contribution to journalArticle

Abstract

Clinical outcome of Schistosoma haematobium infection may vary significantly, ranging from mild symptoms to severe damage of urinary tract organs. This present study was undertaken to assess the relationship of a number of epidemiological and parasitological parameters with disease outcome in children from rural Zimbabwe. We surveyed 551 primary school students from three schools in the Chikwaka Communal Lands for schistosomiasis; 59.7% were infected with S. haematobium. Ultrasound examination of 189 of the infected students revealed that 50% had pathological changes of their bladder and 36% had abnormal pyelon dilation of at least one of their kidneys. Intensity of infection, certain water contact behaviours, male gender, proteinuria, and self-perceived haematuria were associated with increased bladder damage. Strenuous playing was negatively associated with pathology, especially for those with the highest grade of bladder damage. Kidney pathology was significantly linked with fatigue and pain upon urination and was more prevalent in students from schools closest to the major river systems. Our findings suggest that pathology due to urinary schistosomiasis is widespread and symptomatic in this population. The associations with bladder and kidney pathology can be used to predict disease severity and may be useful in targeting treatment to those most at risk.

Original languageEnglish (US)
Pages (from-to)339-347
Number of pages9
JournalActa Tropica
Volume85
Issue number3
DOIs
StatePublished - Mar 1 2003

Fingerprint

Schistosoma haematobium
Zimbabwe
bladder
Urinary Bladder
kidneys
Pathology
Kidney
Students
students
Schistosomiasis haematobia
elementary students
urination
hematuria
schistosomiasis
Urination
Schistosomiasis
urinary tract
Hematuria
Infection
Urinary Tract

Keywords

  • Bladder
  • Kidney
  • Pathology
  • Schistosomiasis
  • Ultrasound

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Epidemiological assessment of Schistosoma haematobium-induced kidney and bladder pathology in rural Zimbabwe. / Brouwer, Kimberly C.; Ndhlovu, Patricia D.; Wagatsuma, Yukiko; Munatsi, Anderson; Shiff, Clive Julian.

In: Acta Tropica, Vol. 85, No. 3, 01.03.2003, p. 339-347.

Research output: Contribution to journalArticle

Brouwer, Kimberly C. ; Ndhlovu, Patricia D. ; Wagatsuma, Yukiko ; Munatsi, Anderson ; Shiff, Clive Julian. / Epidemiological assessment of Schistosoma haematobium-induced kidney and bladder pathology in rural Zimbabwe. In: Acta Tropica. 2003 ; Vol. 85, No. 3. pp. 339-347.
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