Epidemiological and clinicopathological characteristics of bkca-positive and BRCA-negative breast cancer patients in Greece

Olga Triantafyllidou, Ioannis S. Vlachos, Paraskevi Apostolou, Irene Konstantopoulou, Anastasios Grivas, Christos Panopoulos, Constantine Dimitrakakis, Dimitrios Kassanos, Constantine Loghis, Ioannis Bramis, Nikolaos Vlahos, Drakoulis Yannoukakos, Florentia Fostira

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Purpose: BRCA mutation carriers can benefit from targeted clinical interventions. On the other hand, families with evident aggregation of breast cancer (BC) cases and a BRCA-negative genetic test can still be considered as of elevated risk, since the underlying genetic factor remains unidentified. In the present study, we compared clinical and demographic characteristics between BRCA1 mutation carriers (BRCAlmut) and non-carriers (non-BRCAl) in a Greek group of BC patients (n=321). Methods: Data were collected and analyzed from 321 women with BC, with 131 patients screened for pathogenic mutations in the high-penetrant genes BRCA1 and BRCA2. Collected data included demographics, pedigrees, tumor histopathology and immunohistochemistry findings. Results: In BRCAlmut patients, their mothers and grandmothers were diagnosed at a younger age compared to non-BRCAl-carriers. Additionally, BRCAlmut patients were diagnosed with mainly estrogen receptor (ER) negative (p<0.001), Her-2 negative (p<0.05) and triple negative (p<0.01) tumors. The youngest generation was diagnosed with familial breast cancer (FBC) 9.7 years earlier than their mothers (p<0.001). Age at BC diagnosis negatively correlated with the nuclear grade of breast tumors (r=-0.3, p<0.05). Among parous individuals, the number of fullterm pregnancies significantly correlated with the age at BC onset (r=0.19, p<0.05). Conclusion: Despite their similarities, FBC cases with identified BRCA1 mutations exhibit a clearly distinct profile. We have identified an anticipation effect in FBC patients, with significantly reduced age at diagnosis in younger generations. Increased parity seems to prevent early BC onset. This is the first study comparing clinical and demographic characteristics of FBC BRCAlmut and non-carriers in a Greek cohort.

    Original languageEnglish (US)
    Pages (from-to)978-984
    Number of pages7
    JournalJournal of B.U.ON.
    Volume20
    Issue number4
    StatePublished - Jul 1 2015

    Keywords

    • BRCA1
    • BRCA2
    • Hereditary breast cancer
    • Mutations
    • Triple negative breast cancer

    ASJC Scopus subject areas

    • Hematology
    • Oncology
    • Radiology Nuclear Medicine and imaging
    • Cancer Research

    Fingerprint Dive into the research topics of 'Epidemiological and clinicopathological characteristics of bkca-positive and BRCA-negative breast cancer patients in Greece'. Together they form a unique fingerprint.

    Cite this