TY - JOUR
T1 - Epidemiologic study of insect allergy in children. II. Effect of accidental stings in allergic children
AU - Schuberth, Kenneth C.
AU - Lichtenstein, Lawrrence M.
AU - Kagey-Sobatka, Anne
AU - Szklo, Moyses
AU - Kwiterovich, Kathleen A.
AU - Valentine, Martin D.
N1 - Funding Information:
From the Departments of Pediatrics, Medicine, and Epidemiology, The Johns Hopkins University School of Medicine at The Good Samaritan Hospital. Supported by Grant AI 15443, the National Institutes of Health. Publication 491, O'Neill Research Laboratories, The Good Samaritan Hospital, Baltimore, Md. Reprint address Martin D. Valentine, M.D., Division of Clinical Immunology, The Good Samaritan Hospital, 5601 Loch Raven Blvd., Baltimore, MD 21239,
PY - 1983/3
Y1 - 1983/3
N2 - One hundred eighty-one children with non-life-threatening reactions to insect stings and positive venom skin tests were randomized to treatment (53) or no-treatment (128) groups and followed up clinically and immunologically for at least two years to assess the results of accidental stings. Twenty-eight stings in 17 treated patients and 74 stings in 47 untreated children occurred, leading to one mild reaction in a treated patient, and eight in the no-treatment group (P=NS). No reaction was more serious than the original. Based on IgE antibody changes and skin test results, 87% of the untreated children were stung by insect to which they had clinical sensitivity by skin test. Vespid skin test sensitivity decreased 10-fold or more in both treated (72%) and untreated (44%) children. Of those with increased sensitivity. ≅ 70% had been stung. These data indicate that the incidence of sever reactions on resting is low in insect-allergic children, and that the majority show decreased skin test sensitivity over time.
AB - One hundred eighty-one children with non-life-threatening reactions to insect stings and positive venom skin tests were randomized to treatment (53) or no-treatment (128) groups and followed up clinically and immunologically for at least two years to assess the results of accidental stings. Twenty-eight stings in 17 treated patients and 74 stings in 47 untreated children occurred, leading to one mild reaction in a treated patient, and eight in the no-treatment group (P=NS). No reaction was more serious than the original. Based on IgE antibody changes and skin test results, 87% of the untreated children were stung by insect to which they had clinical sensitivity by skin test. Vespid skin test sensitivity decreased 10-fold or more in both treated (72%) and untreated (44%) children. Of those with increased sensitivity. ≅ 70% had been stung. These data indicate that the incidence of sever reactions on resting is low in insect-allergic children, and that the majority show decreased skin test sensitivity over time.
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U2 - 10.1016/S0022-3476(83)80649-0
DO - 10.1016/S0022-3476(83)80649-0
M3 - Article
C2 - 6827407
AN - SCOPUS:0020680899
SN - 0022-3476
VL - 102
SP - 361
EP - 365
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 3
ER -