Epidemiologic studies of glyphosate and cancer: A review

Pamela J. Mink, Jack S. Mandel, Bonnielin Swenor, Jessica I. Lundin

Research output: Contribution to journalArticle

Abstract

The United States Environmental Protection Agency and other regulatory agencies around the world have registered glyphosate as a broad-spectrum herbicide for use on multiple food and non-food use crops. Glyphosate is widely considered by regulatory authorities and scientific bodies to have no carcinogenic potential, based primarily on results of carcinogenicity studies of rats and mice. To examine potential cancer risks in humans, we reviewed the epidemiologic literature to evaluate whether exposure to glyphosate is associated causally with cancer risk in humans. We also reviewed relevant methodological and biomonitoring studies of glyphosate. Seven cohort studies and fourteen case-control studies examined the association between glyphosate and one or more cancer outcomes. Our review found no consistent pattern of positive associations indicating a causal relationship between total cancer (in adults or children) or any site-specific cancer and exposure to glyphosate. Data from biomonitoring studies underscore the importance of exposure assessment in epidemiologic studies, and indicate that studies should incorporate not only duration and frequency of pesticide use, but also type of pesticide formulation. Because generic exposure assessments likely lead to exposure misclassification, it is recommended that exposure algorithms be validated with biomonitoring data.

Original languageEnglish (US)
Pages (from-to)440-452
Number of pages13
JournalRegulatory Toxicology and Pharmacology
Volume63
Issue number3
DOIs
StatePublished - Aug 2012

Fingerprint

glyphosate
Epidemiologic Studies
Environmental Monitoring
Neoplasms
Pesticides
United States Environmental Protection Agency
Environmental Protection Agency
Herbicides
Crops
Case-Control Studies
Rats
Cohort Studies

Keywords

  • Cancer
  • Epidemiology
  • Glyphosate
  • Herbicides

ASJC Scopus subject areas

  • Toxicology

Cite this

Epidemiologic studies of glyphosate and cancer : A review. / Mink, Pamela J.; Mandel, Jack S.; Swenor, Bonnielin; Lundin, Jessica I.

In: Regulatory Toxicology and Pharmacology, Vol. 63, No. 3, 08.2012, p. 440-452.

Research output: Contribution to journalArticle

Mink, Pamela J. ; Mandel, Jack S. ; Swenor, Bonnielin ; Lundin, Jessica I. / Epidemiologic studies of glyphosate and cancer : A review. In: Regulatory Toxicology and Pharmacology. 2012 ; Vol. 63, No. 3. pp. 440-452.
@article{99be84251bdb4953928ff23b2c1027be,
title = "Epidemiologic studies of glyphosate and cancer: A review",
abstract = "The United States Environmental Protection Agency and other regulatory agencies around the world have registered glyphosate as a broad-spectrum herbicide for use on multiple food and non-food use crops. Glyphosate is widely considered by regulatory authorities and scientific bodies to have no carcinogenic potential, based primarily on results of carcinogenicity studies of rats and mice. To examine potential cancer risks in humans, we reviewed the epidemiologic literature to evaluate whether exposure to glyphosate is associated causally with cancer risk in humans. We also reviewed relevant methodological and biomonitoring studies of glyphosate. Seven cohort studies and fourteen case-control studies examined the association between glyphosate and one or more cancer outcomes. Our review found no consistent pattern of positive associations indicating a causal relationship between total cancer (in adults or children) or any site-specific cancer and exposure to glyphosate. Data from biomonitoring studies underscore the importance of exposure assessment in epidemiologic studies, and indicate that studies should incorporate not only duration and frequency of pesticide use, but also type of pesticide formulation. Because generic exposure assessments likely lead to exposure misclassification, it is recommended that exposure algorithms be validated with biomonitoring data.",
keywords = "Cancer, Epidemiology, Glyphosate, Herbicides",
author = "Mink, {Pamela J.} and Mandel, {Jack S.} and Bonnielin Swenor and Lundin, {Jessica I.}",
year = "2012",
month = "8",
doi = "10.1016/j.yrtph.2012.05.012",
language = "English (US)",
volume = "63",
pages = "440--452",
journal = "Regulatory Toxicology and Pharmacology",
issn = "0273-2300",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Epidemiologic studies of glyphosate and cancer

T2 - A review

AU - Mink, Pamela J.

AU - Mandel, Jack S.

AU - Swenor, Bonnielin

AU - Lundin, Jessica I.

PY - 2012/8

Y1 - 2012/8

N2 - The United States Environmental Protection Agency and other regulatory agencies around the world have registered glyphosate as a broad-spectrum herbicide for use on multiple food and non-food use crops. Glyphosate is widely considered by regulatory authorities and scientific bodies to have no carcinogenic potential, based primarily on results of carcinogenicity studies of rats and mice. To examine potential cancer risks in humans, we reviewed the epidemiologic literature to evaluate whether exposure to glyphosate is associated causally with cancer risk in humans. We also reviewed relevant methodological and biomonitoring studies of glyphosate. Seven cohort studies and fourteen case-control studies examined the association between glyphosate and one or more cancer outcomes. Our review found no consistent pattern of positive associations indicating a causal relationship between total cancer (in adults or children) or any site-specific cancer and exposure to glyphosate. Data from biomonitoring studies underscore the importance of exposure assessment in epidemiologic studies, and indicate that studies should incorporate not only duration and frequency of pesticide use, but also type of pesticide formulation. Because generic exposure assessments likely lead to exposure misclassification, it is recommended that exposure algorithms be validated with biomonitoring data.

AB - The United States Environmental Protection Agency and other regulatory agencies around the world have registered glyphosate as a broad-spectrum herbicide for use on multiple food and non-food use crops. Glyphosate is widely considered by regulatory authorities and scientific bodies to have no carcinogenic potential, based primarily on results of carcinogenicity studies of rats and mice. To examine potential cancer risks in humans, we reviewed the epidemiologic literature to evaluate whether exposure to glyphosate is associated causally with cancer risk in humans. We also reviewed relevant methodological and biomonitoring studies of glyphosate. Seven cohort studies and fourteen case-control studies examined the association between glyphosate and one or more cancer outcomes. Our review found no consistent pattern of positive associations indicating a causal relationship between total cancer (in adults or children) or any site-specific cancer and exposure to glyphosate. Data from biomonitoring studies underscore the importance of exposure assessment in epidemiologic studies, and indicate that studies should incorporate not only duration and frequency of pesticide use, but also type of pesticide formulation. Because generic exposure assessments likely lead to exposure misclassification, it is recommended that exposure algorithms be validated with biomonitoring data.

KW - Cancer

KW - Epidemiology

KW - Glyphosate

KW - Herbicides

UR - http://www.scopus.com/inward/record.url?scp=84862733778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862733778&partnerID=8YFLogxK

U2 - 10.1016/j.yrtph.2012.05.012

DO - 10.1016/j.yrtph.2012.05.012

M3 - Article

C2 - 22683395

AN - SCOPUS:84862733778

VL - 63

SP - 440

EP - 452

JO - Regulatory Toxicology and Pharmacology

JF - Regulatory Toxicology and Pharmacology

SN - 0273-2300

IS - 3

ER -