TY - JOUR
T1 - Epidemiologic differences between the two varieties of Cryptococcus neoformans
AU - Kwon-chung, K. J.
AU - Bennett, J. E.
PY - 1984/7
Y1 - 1984/7
N2 - This report of the worldwide distribution of two varieties of Cryptococcus neoformans was drawn from data on 628 clinical isolates and from data on 97 additional isolates from other laboratories. Tests showed that 100% of the cultures from Austria, Belgium, Denmark, France, Germany, Holland, Italy, Switzerland, and Japan belonged to C. neoformans var. neoformans. More than 85% of the isolates from Argentina, Canada, the United Kingdom, and the United States (except southern California) were of C. neoformans var. neoformans, the remainder being of C. neoformans var. gattil. There was an unusually high prevalence (35-100%) of C. neoformans var. gattil in Australia, Brazil, Cambodia, Hawali, southern California, Mexico, Paraguay, Thailand, Vietnam, Nepal, and countries in central Africa. These findings indicated that C. neoformans var. gattil is prevalent only in tropical and subtropical regions. Seventy per cent of the total isolates studied were of serotype A of C. neoformans var. neoformans. Serotype D (9% of the total) was common in Europe, but was found infrequently in other regions. Among the two serotypes of C. neoformans var. gattil, serotype B was 4.5 times more prevalent than serotype C. The majority (88%) of type C isolates in our collection were from southern California.
AB - This report of the worldwide distribution of two varieties of Cryptococcus neoformans was drawn from data on 628 clinical isolates and from data on 97 additional isolates from other laboratories. Tests showed that 100% of the cultures from Austria, Belgium, Denmark, France, Germany, Holland, Italy, Switzerland, and Japan belonged to C. neoformans var. neoformans. More than 85% of the isolates from Argentina, Canada, the United Kingdom, and the United States (except southern California) were of C. neoformans var. neoformans, the remainder being of C. neoformans var. gattil. There was an unusually high prevalence (35-100%) of C. neoformans var. gattil in Australia, Brazil, Cambodia, Hawali, southern California, Mexico, Paraguay, Thailand, Vietnam, Nepal, and countries in central Africa. These findings indicated that C. neoformans var. gattil is prevalent only in tropical and subtropical regions. Seventy per cent of the total isolates studied were of serotype A of C. neoformans var. neoformans. Serotype D (9% of the total) was common in Europe, but was found infrequently in other regions. Among the two serotypes of C. neoformans var. gattil, serotype B was 4.5 times more prevalent than serotype C. The majority (88%) of type C isolates in our collection were from southern California.
KW - Ctyptococcus neoformans
KW - Epidemiologic methods
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U2 - 10.1093/oxfordjournals.aje.a113861
DO - 10.1093/oxfordjournals.aje.a113861
M3 - Article
C2 - 6377880
AN - SCOPUS:0021266798
SN - 0002-9262
VL - 120
SP - 123
EP - 130
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 1
ER -