TY - JOUR
T1 - Epidemiologic and clinical features of other enteric viruses associated with acute gastroenteritis in American Indian infants
AU - Grant, Lindsay
AU - Vinjé, Jan
AU - Parashar, Umesh
AU - Watt, James
AU - Reid, Raymond
AU - Weatherholtz, Robert
AU - Santosham, Mathuram
AU - Gentsch, Jon
AU - O'Brien, Katherine
N1 - Funding Information:
Funded by Merck & Co. and Centers for Disease Control and Prevention . M.S. has served as a consultant for GlaxoSmithKline and Merck & Co . J.W., R.R., M.S., K.B., L.G., and R.W. received grant funding from Merck & Co for conduct of the original rotavirus vaccine trial. The findings and conclusions in this paper are those of the authors and do not necessarily reflect the views of the Indian Health Service or the Centers for Disease Control and Prevention. The other authors declare no conflicts of interest.
PY - 2012/7
Y1 - 2012/7
N2 - Objective: To investigate the viral etiology, through the use of molecular methods, of acute gastroenteritis (AGE), which is a considerable public health burden in Native American infants. Study design: From March 2002 through February 2004, AGE and non-diarrheal stools were collected from Navajo and White Mountain Apache infants who received placebo during a rotavirus vaccine trial. Case (n = 247) and control (n = 344) specimens were tested for enteric adenovirus, astrovirus, norovirus, rotavirus, and sapovirus with real-time polymerase chain reaction. The odds of AGE were compared with population-averaged logistic regression models. Results: In 65% of the cases of AGE (161/247), at least one virus was detected; norovirus (n = 80, 32%) and rotavirus (n = 70, 28%) were the most common. A virus was detected in 38% of control specimens (132/344). Detection of "any virus" was associated with AGE (OR = 3.22; 95% CI, 2.11-4.91), as was detection of norovirus (OR = 2.00; 95% CI, 1.22-3.26) and rotavirus (OR = 2.69; 95% CI, 1.52-4.79). Conclusion: This study highlights the significant burden of viral AGE in American Indian infants and identifies pathogen targets for future prevention efforts in this population.
AB - Objective: To investigate the viral etiology, through the use of molecular methods, of acute gastroenteritis (AGE), which is a considerable public health burden in Native American infants. Study design: From March 2002 through February 2004, AGE and non-diarrheal stools were collected from Navajo and White Mountain Apache infants who received placebo during a rotavirus vaccine trial. Case (n = 247) and control (n = 344) specimens were tested for enteric adenovirus, astrovirus, norovirus, rotavirus, and sapovirus with real-time polymerase chain reaction. The odds of AGE were compared with population-averaged logistic regression models. Results: In 65% of the cases of AGE (161/247), at least one virus was detected; norovirus (n = 80, 32%) and rotavirus (n = 70, 28%) were the most common. A virus was detected in 38% of control specimens (132/344). Detection of "any virus" was associated with AGE (OR = 3.22; 95% CI, 2.11-4.91), as was detection of norovirus (OR = 2.00; 95% CI, 1.22-3.26) and rotavirus (OR = 2.69; 95% CI, 1.52-4.79). Conclusion: This study highlights the significant burden of viral AGE in American Indian infants and identifies pathogen targets for future prevention efforts in this population.
UR - http://www.scopus.com/inward/record.url?scp=84862753489&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862753489&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2011.12.046
DO - 10.1016/j.jpeds.2011.12.046
M3 - Article
C2 - 22336577
AN - SCOPUS:84862753489
SN - 0022-3476
VL - 161
SP - 110-115.e1
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 1
ER -