TY - JOUR
T1 - Epidemic hepatitis e in pakistan
T2 - Patterns of serologic response and evidence that antibody to hepatitis e virus protects against disease
AU - Bryan, Joe P.
AU - Tsarev, Sergei A.
AU - Iqbal, Mohammed
AU - Ticehurst, John
AU - Emerson, Suzanne
AU - Ahmed, Aftab
AU - Duncan, John
AU - Rauf Rafiqui, A.
AU - Malik, Iftikhar A.
AU - Purcell, Robert H.
AU - Legters, Llewellyn J.
N1 - Funding Information:
Received 27 December 1993; revised 18 April 1994. Presented: Annual meeting of the American Society for Tropical Medicine and Hygiene. Atlanta. 31 October-4 November 1993; 1993 International Society of Hepatitis and Liver Disease. Tokyo. May 1993. Informed consent was obtained from patients and contacts. Guidelines for the ethical use of human subjects at Uniformed Services University of the Health Sciences and Army Medical College were followed. Opinions and assertions contained herein are those of the authors and do not necessarily represent those of the Department of Defense or the Uniformed Services University of the Health Sciences. Financial support: US Army Research and Development Command (DAMD 17-83-G-952I ). Reprints or correspondence: Dr. Joe P. Bryan. Dept. of Preventive Medicine and Biometrics. Uniformed Services University ofthe Health Sciences. Bethesda. MD 20814-4799. *Present affiliation: Department of Pathology. Johns Hopkins University School of Medicine. Baltimore.
PY - 1994/9
Y1 - 1994/9
N2 - IgM and IgG anti-hepatitis E virus (HEV) patterns were determined in sera collected during a hepatitis outbreak in Pakistan. HEV infection was detected serologically in 122 patients. IgM anti-HEY was detected in specimens collected up to 2 weeks before and 5-7 weeks after hospitalization in 91% and 100%, respectively, of 122 HEV-infected patients. IgG followed a similar pattern. Peak antibody titers appeared 2-4 weeks after hospitalization. At 20 months after hospitalization, IgM anti-HEY was not detected in any of 33 patients; IgG was found in all. IgG anti-HEV appeared to be protective in contacts of patients. This study confirms HEV as the cause of the outbreak, quantifies IgM and IgG anti-HEY responses, provides evidence that IgG anti-HEY protects against hepatitis E, and demonstrates that IgG anti-HEY persists, but at diminished titer, after infection. Hepatitis E in young adults is the result of primary infection with HEV and, if reinfection occurs, it does not commonly cause serious illness.
AB - IgM and IgG anti-hepatitis E virus (HEV) patterns were determined in sera collected during a hepatitis outbreak in Pakistan. HEV infection was detected serologically in 122 patients. IgM anti-HEY was detected in specimens collected up to 2 weeks before and 5-7 weeks after hospitalization in 91% and 100%, respectively, of 122 HEV-infected patients. IgG followed a similar pattern. Peak antibody titers appeared 2-4 weeks after hospitalization. At 20 months after hospitalization, IgM anti-HEY was not detected in any of 33 patients; IgG was found in all. IgG anti-HEV appeared to be protective in contacts of patients. This study confirms HEV as the cause of the outbreak, quantifies IgM and IgG anti-HEY responses, provides evidence that IgG anti-HEY protects against hepatitis E, and demonstrates that IgG anti-HEY persists, but at diminished titer, after infection. Hepatitis E in young adults is the result of primary infection with HEV and, if reinfection occurs, it does not commonly cause serious illness.
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U2 - 10.1093/infdis/170.3.517
DO - 10.1093/infdis/170.3.517
M3 - Article
C2 - 8077708
AN - SCOPUS:0028021475
SN - 0022-1899
VL - 170
SP - 517
EP - 521
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -