Epidemic hepatitis e in pakistan: Patterns of serologic response and evidence that antibody to hepatitis e virus protects against disease

Joe P. Bryan, Sergei A. Tsarev, Mohammed Iqbal, John Ticehurst, Suzanne Emerson, Aftab Ahmed, John Duncan, A. Rauf Rafiqui, Iftikhar A. Malik, Robert H. Purcell, Llewellyn J. Legters

Research output: Contribution to journalArticle

Abstract

IgM and IgG anti-hepatitis E virus (HEV) patterns were determined in sera collected during a hepatitis outbreak in Pakistan. HEV infection was detected serologically in 122 patients. IgM anti-HEY was detected in specimens collected up to 2 weeks before and 5-7 weeks after hospitalization in 91% and 100%, respectively, of 122 HEV-infected patients. IgG followed a similar pattern. Peak antibody titers appeared 2-4 weeks after hospitalization. At 20 months after hospitalization, IgM anti-HEY was not detected in any of 33 patients; IgG was found in all. IgG anti-HEV appeared to be protective in contacts of patients. This study confirms HEV as the cause of the outbreak, quantifies IgM and IgG anti-HEY responses, provides evidence that IgG anti-HEY protects against hepatitis E, and demonstrates that IgG anti-HEY persists, but at diminished titer, after infection. Hepatitis E in young adults is the result of primary infection with HEV and, if reinfection occurs, it does not commonly cause serious illness.

Original languageEnglish (US)
Pages (from-to)517-521
Number of pages5
JournalJournal of Infectious Diseases
Volume170
Issue number3
DOIs
StatePublished - Sep 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Bryan, J. P., Tsarev, S. A., Iqbal, M., Ticehurst, J., Emerson, S., Ahmed, A., Duncan, J., Rauf Rafiqui, A., Malik, I. A., Purcell, R. H., & Legters, L. J. (1994). Epidemic hepatitis e in pakistan: Patterns of serologic response and evidence that antibody to hepatitis e virus protects against disease. Journal of Infectious Diseases, 170(3), 517-521. https://doi.org/10.1093/infdis/170.3.517