Ependymoma and intraparenchymal calcifying pseudoneoplasm of the neural axis: Incidental collision or unique reactive phenomenon?

Fausto J. Rodriguez, Bernd W. Scheithauer, Daryl R. Fourney, Christopher A. Robinson

Research output: Contribution to journalArticlepeer-review

Abstract

The so-called "calcifying pseudoneoplasm of the neural axis" is a rare tumefactive lesion presumed to be reactive in nature. To our knowledge, association with a true neoplasm has not been previously reported. We recently encountered the case of a 67-year-old woman who underwent resection of an incidentally discovered cerebellar cystic mass with a distinct, calcified component. Histology demonstrated a partially ossified, lobulated, chondrocalcific lesion surrounded by chronic inflammation, spindle to epithelioid cells, and occasional multinucleated giant cells - all features of calcifying pseudoneoplasm of the neural axis. A low-grade ependymoma associated with marked piloid gliosis was found contiguous to the lesion. The unique combination of an ependymoma with marked reactive gliosis and a calcifying pseudoneoplasm supports the reactive nature of the latter.

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalActa neuropathologica
Volume115
Issue number3
DOIs
StatePublished - Mar 2008

Keywords

  • Brain
  • Calcifying pseudoneoplasm
  • Central nervous system
  • Ependymoma
  • Neural axis
  • Reactive fibro-osseous lesion

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Ependymoma and intraparenchymal calcifying pseudoneoplasm of the neural axis: Incidental collision or unique reactive phenomenon?'. Together they form a unique fingerprint.

Cite this