Eosinophils in autoimmune diseases

Nicola L. Diny, Noel R. Rose, Daniela Cihakova

Research output: Contribution to journalReview article

Abstract

Eosinophils are multifunctional granulocytes that contribute to initiation and modulation of inflammation. Their role in asthma and parasitic infections has long been recognized. Growing evidence now reveals a role for eosinophils in autoimmune diseases. In this review, we summarize the function of eosinophils in inflammatory bowel diseases, neuromyelitis optica, bullous pemphigoid, autoimmune myocarditis, primary biliary cirrhosis, eosinophilic granulomatosis with polyangiitis, and other autoimmune diseases. Clinical studies, eosinophil-targeted therapies, and experimental models have contributed to our understanding of the regulation and function of eosinophils in these diseases. By examining the role of eosinophils in autoimmune diseases of different organs, we can identify common pathogenic mechanisms. These include degranulation of cytotoxic granule proteins, induction of antibody-dependent cell-mediated cytotoxicity, release of proteases degrading extracellular matrix, immune modulation through cytokines, antigen presentation, and prothrombotic functions. The association of eosinophilic diseases with autoimmune diseases is also examined, showing a possible increase in autoimmune diseases in patients with eosinophilic esophagitis, hypereosinophilic syndrome, and non-allergic asthma. Finally, we summarize key future research needs.

Original languageEnglish (US)
Article number484
JournalFrontiers in Immunology
Volume8
Issue numberAPR
DOIs
StatePublished - Apr 27 2017

    Fingerprint

Keywords

  • Autoimmune diseases
  • Bullous pemphigoid
  • Eosinophilia
  • Eosinophilic granulomatosis with polyangiitis
  • Inflammatory bowel disease
  • Innate immune system
  • Myocarditis
  • Neuromyelitis optica

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this