Eosinophilic sialodochitis: Redefinition of 'allergic parotitis' and 'sialodochitis fibrinosa'

Alan Baer, A. Okuhama, David W Eisele, Jody R Tversky, Tj Gniadek

Research output: Contribution to journalArticle

Abstract

Sialodochitis fibrinosa and allergic parotitis have described rare patients with recurrent salivary gland swelling and mucus plugs, often with atopy. We have evaluated three patients with atopic disease, recurrent salivary gland swelling, and an eosinophilic sialodochitis. Two had eosinophil-rich mucus plugs. Fifty-six additional cases were identified in a medical literature database search, each defined by recurrent salivary gland swelling associated with eosinophil-rich mucus plugs or sialodochitis with periductal eosinophilic infiltration. The majority (78%) were reported from Japan. Females were predominantly affected (F:M = 2.3) with a median age of 47 years at evaluation. The parotid and submandibular glands were involved, respectively, in 71% and 46%. Allergic symptoms were present in 66%, atopic disease in 63% of those with reported allergy testing, and blood eosinophilia in 71%. Contrast sialography and other imaging modalities documented ductal dilatation in 82%. Treatments included anti-allergic medications (58%), systemic glucocorticoids (25%), duct cannulation with irrigation, steroid injection, and/or duct dilatation (36%), and glandular resection (19%). We recommend the diagnosis 'eosinophilic sialodochitis' be applied to patients who meet this case definition. The disease is a unique cause of chronic recurrent salivary gland swelling. Its likely allergic etiology may be amenable to current or future biologic therapies.

Original languageEnglish (US)
JournalOral Diseases
DOIs
StateAccepted/In press - 2016

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Parotitis
Mucus
Salivary Glands
Eosinophils
Dilatation
Salivary Gland Diseases
Sialography
Anti-Allergic Agents
Biological Therapy
Submandibular Gland
Parotid Gland
Eosinophilia
Catheterization
Glucocorticoids
Japan
Hypersensitivity
Steroids
Databases
Injections
Therapeutics

Keywords

  • Allergic parotitis
  • Eosinophils
  • Kussmaul disease
  • Salivary gland
  • Sialodochitis fibrinosa

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)

Cite this

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title = "Eosinophilic sialodochitis: Redefinition of 'allergic parotitis' and 'sialodochitis fibrinosa'",
abstract = "Sialodochitis fibrinosa and allergic parotitis have described rare patients with recurrent salivary gland swelling and mucus plugs, often with atopy. We have evaluated three patients with atopic disease, recurrent salivary gland swelling, and an eosinophilic sialodochitis. Two had eosinophil-rich mucus plugs. Fifty-six additional cases were identified in a medical literature database search, each defined by recurrent salivary gland swelling associated with eosinophil-rich mucus plugs or sialodochitis with periductal eosinophilic infiltration. The majority (78{\%}) were reported from Japan. Females were predominantly affected (F:M = 2.3) with a median age of 47 years at evaluation. The parotid and submandibular glands were involved, respectively, in 71{\%} and 46{\%}. Allergic symptoms were present in 66{\%}, atopic disease in 63{\%} of those with reported allergy testing, and blood eosinophilia in 71{\%}. Contrast sialography and other imaging modalities documented ductal dilatation in 82{\%}. Treatments included anti-allergic medications (58{\%}), systemic glucocorticoids (25{\%}), duct cannulation with irrigation, steroid injection, and/or duct dilatation (36{\%}), and glandular resection (19{\%}). We recommend the diagnosis 'eosinophilic sialodochitis' be applied to patients who meet this case definition. The disease is a unique cause of chronic recurrent salivary gland swelling. Its likely allergic etiology may be amenable to current or future biologic therapies.",
keywords = "Allergic parotitis, Eosinophils, Kussmaul disease, Salivary gland, Sialodochitis fibrinosa",
author = "Alan Baer and A. Okuhama and Eisele, {David W} and Tversky, {Jody R} and Tj Gniadek",
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language = "English (US)",
journal = "Oral Diseases",
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T2 - Redefinition of 'allergic parotitis' and 'sialodochitis fibrinosa'

AU - Baer, Alan

AU - Okuhama, A.

AU - Eisele, David W

AU - Tversky, Jody R

AU - Gniadek, Tj

PY - 2016

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N2 - Sialodochitis fibrinosa and allergic parotitis have described rare patients with recurrent salivary gland swelling and mucus plugs, often with atopy. We have evaluated three patients with atopic disease, recurrent salivary gland swelling, and an eosinophilic sialodochitis. Two had eosinophil-rich mucus plugs. Fifty-six additional cases were identified in a medical literature database search, each defined by recurrent salivary gland swelling associated with eosinophil-rich mucus plugs or sialodochitis with periductal eosinophilic infiltration. The majority (78%) were reported from Japan. Females were predominantly affected (F:M = 2.3) with a median age of 47 years at evaluation. The parotid and submandibular glands were involved, respectively, in 71% and 46%. Allergic symptoms were present in 66%, atopic disease in 63% of those with reported allergy testing, and blood eosinophilia in 71%. Contrast sialography and other imaging modalities documented ductal dilatation in 82%. Treatments included anti-allergic medications (58%), systemic glucocorticoids (25%), duct cannulation with irrigation, steroid injection, and/or duct dilatation (36%), and glandular resection (19%). We recommend the diagnosis 'eosinophilic sialodochitis' be applied to patients who meet this case definition. The disease is a unique cause of chronic recurrent salivary gland swelling. Its likely allergic etiology may be amenable to current or future biologic therapies.

AB - Sialodochitis fibrinosa and allergic parotitis have described rare patients with recurrent salivary gland swelling and mucus plugs, often with atopy. We have evaluated three patients with atopic disease, recurrent salivary gland swelling, and an eosinophilic sialodochitis. Two had eosinophil-rich mucus plugs. Fifty-six additional cases were identified in a medical literature database search, each defined by recurrent salivary gland swelling associated with eosinophil-rich mucus plugs or sialodochitis with periductal eosinophilic infiltration. The majority (78%) were reported from Japan. Females were predominantly affected (F:M = 2.3) with a median age of 47 years at evaluation. The parotid and submandibular glands were involved, respectively, in 71% and 46%. Allergic symptoms were present in 66%, atopic disease in 63% of those with reported allergy testing, and blood eosinophilia in 71%. Contrast sialography and other imaging modalities documented ductal dilatation in 82%. Treatments included anti-allergic medications (58%), systemic glucocorticoids (25%), duct cannulation with irrigation, steroid injection, and/or duct dilatation (36%), and glandular resection (19%). We recommend the diagnosis 'eosinophilic sialodochitis' be applied to patients who meet this case definition. The disease is a unique cause of chronic recurrent salivary gland swelling. Its likely allergic etiology may be amenable to current or future biologic therapies.

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