Eosinophil and T cell markers predict functional decline in COPD patients

Jeanine M. D'Armiento, Steven M. Scharf, Michael D. Roth, John E. Connett, Andrew Ghio, David Sternberg, Jonathan G. Goldin, Thomas Louis, Jenny T. Mao, George T. O'Connor, Joe W. Ramsdell, Andrew L. Ries, Neil W. Schluger, Frank C. Sciurba, Melissa A. Skeans, Helen Voelker, Robert E. Walter, Christine H. Wendt, Gail G. Weinmann, Robert A Wise & 1 others Robert F. Foronjy

Research output: Contribution to journalArticle

Abstract

Background: The major marker utilized to monitor COPD patients is forced expiratory volume in one second (FEV1). However, asingle measurement of FEV1 cannot reliably predict subsequent decline. Recent studies indicate that T lymphocytes and eosinophils are important determinants of disease stability in COPD. We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease.Methods: Baseline lung lavage and plasma samples were collected from COPD subjects with moderately severe airway obstruction and emphysematous changes on chest CT. The study participants were former smokers who had not had a disease exacerbation within the past six months or used steroids within the past two months. Those subjects who demonstrated stable disease over the following six months (ΔFEV1 % predicted = 4.7 ± 7.2; N = 34) were retrospectively compared with study participants who experienced a rapid decline in lung function (ΔFEV1 % predicted = -16.0 ± 6.0; N = 16) during the same time period and with normal controls (N = 11). Plasma and lung lavage cytokines were measured from clinical samples using the Luminex multiplex kit which enabled the simultaneous measurement of several T cell and eosinophil related cytokines.Results and Discussion: Stable COPD participants had significantly higher plasma IL-2 levels compared to participants with rapidly progressive COPD (p = 0.04). In contrast, plasma eotaxin-1 levels were significantly lower in stable COPD subjects compared to normal controls (p <0.03). In addition, lung lavage eotaxin-1 levels were significantly higher in rapidly progressive COPD participants compared to both normal controls (p <0.02) and stable COPD participants (p <0.05).Conclusion: These findings indicate that IL-2 and eotaxin-1 levels may be important markers of disease stability in advanced emphysema patients. Prospective studies will need to confirm whether measuring IL-2 or eotaxin-1 can identify patients at risk for rapid disease progression.

Original languageEnglish (US)
Article number113
JournalRespiratory Research
Volume10
DOIs
StatePublished - Nov 19 2009

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Eosinophils
Chronic Obstructive Pulmonary Disease
Chemokine CCL11
T-Lymphocytes
Bronchoalveolar Lavage
Cytokines
Interleukin-2
Disease Progression
Emphysema
Bronchoalveolar Lavage Fluid
Forced Expiratory Volume
Airway Obstruction
Thorax
Steroids
Prospective Studies
Lung

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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D'Armiento, J. M., Scharf, S. M., Roth, M. D., Connett, J. E., Ghio, A., Sternberg, D., ... Foronjy, R. F. (2009). Eosinophil and T cell markers predict functional decline in COPD patients. Respiratory Research, 10, [113]. https://doi.org/10.1186/1465-9921-10-113

Eosinophil and T cell markers predict functional decline in COPD patients. / D'Armiento, Jeanine M.; Scharf, Steven M.; Roth, Michael D.; Connett, John E.; Ghio, Andrew; Sternberg, David; Goldin, Jonathan G.; Louis, Thomas; Mao, Jenny T.; O'Connor, George T.; Ramsdell, Joe W.; Ries, Andrew L.; Schluger, Neil W.; Sciurba, Frank C.; Skeans, Melissa A.; Voelker, Helen; Walter, Robert E.; Wendt, Christine H.; Weinmann, Gail G.; Wise, Robert A; Foronjy, Robert F.

In: Respiratory Research, Vol. 10, 113, 19.11.2009.

Research output: Contribution to journalArticle

D'Armiento, JM, Scharf, SM, Roth, MD, Connett, JE, Ghio, A, Sternberg, D, Goldin, JG, Louis, T, Mao, JT, O'Connor, GT, Ramsdell, JW, Ries, AL, Schluger, NW, Sciurba, FC, Skeans, MA, Voelker, H, Walter, RE, Wendt, CH, Weinmann, GG, Wise, RA & Foronjy, RF 2009, 'Eosinophil and T cell markers predict functional decline in COPD patients', Respiratory Research, vol. 10, 113. https://doi.org/10.1186/1465-9921-10-113
D'Armiento JM, Scharf SM, Roth MD, Connett JE, Ghio A, Sternberg D et al. Eosinophil and T cell markers predict functional decline in COPD patients. Respiratory Research. 2009 Nov 19;10. 113. https://doi.org/10.1186/1465-9921-10-113
D'Armiento, Jeanine M. ; Scharf, Steven M. ; Roth, Michael D. ; Connett, John E. ; Ghio, Andrew ; Sternberg, David ; Goldin, Jonathan G. ; Louis, Thomas ; Mao, Jenny T. ; O'Connor, George T. ; Ramsdell, Joe W. ; Ries, Andrew L. ; Schluger, Neil W. ; Sciurba, Frank C. ; Skeans, Melissa A. ; Voelker, Helen ; Walter, Robert E. ; Wendt, Christine H. ; Weinmann, Gail G. ; Wise, Robert A ; Foronjy, Robert F. / Eosinophil and T cell markers predict functional decline in COPD patients. In: Respiratory Research. 2009 ; Vol. 10.
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abstract = "Background: The major marker utilized to monitor COPD patients is forced expiratory volume in one second (FEV1). However, asingle measurement of FEV1 cannot reliably predict subsequent decline. Recent studies indicate that T lymphocytes and eosinophils are important determinants of disease stability in COPD. We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease.Methods: Baseline lung lavage and plasma samples were collected from COPD subjects with moderately severe airway obstruction and emphysematous changes on chest CT. The study participants were former smokers who had not had a disease exacerbation within the past six months or used steroids within the past two months. Those subjects who demonstrated stable disease over the following six months (ΔFEV1 {\%} predicted = 4.7 ± 7.2; N = 34) were retrospectively compared with study participants who experienced a rapid decline in lung function (ΔFEV1 {\%} predicted = -16.0 ± 6.0; N = 16) during the same time period and with normal controls (N = 11). Plasma and lung lavage cytokines were measured from clinical samples using the Luminex multiplex kit which enabled the simultaneous measurement of several T cell and eosinophil related cytokines.Results and Discussion: Stable COPD participants had significantly higher plasma IL-2 levels compared to participants with rapidly progressive COPD (p = 0.04). In contrast, plasma eotaxin-1 levels were significantly lower in stable COPD subjects compared to normal controls (p <0.03). In addition, lung lavage eotaxin-1 levels were significantly higher in rapidly progressive COPD participants compared to both normal controls (p <0.02) and stable COPD participants (p <0.05).Conclusion: These findings indicate that IL-2 and eotaxin-1 levels may be important markers of disease stability in advanced emphysema patients. Prospective studies will need to confirm whether measuring IL-2 or eotaxin-1 can identify patients at risk for rapid disease progression.",
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T1 - Eosinophil and T cell markers predict functional decline in COPD patients

AU - D'Armiento, Jeanine M.

AU - Scharf, Steven M.

AU - Roth, Michael D.

AU - Connett, John E.

AU - Ghio, Andrew

AU - Sternberg, David

AU - Goldin, Jonathan G.

AU - Louis, Thomas

AU - Mao, Jenny T.

AU - O'Connor, George T.

AU - Ramsdell, Joe W.

AU - Ries, Andrew L.

AU - Schluger, Neil W.

AU - Sciurba, Frank C.

AU - Skeans, Melissa A.

AU - Voelker, Helen

AU - Walter, Robert E.

AU - Wendt, Christine H.

AU - Weinmann, Gail G.

AU - Wise, Robert A

AU - Foronjy, Robert F.

PY - 2009/11/19

Y1 - 2009/11/19

N2 - Background: The major marker utilized to monitor COPD patients is forced expiratory volume in one second (FEV1). However, asingle measurement of FEV1 cannot reliably predict subsequent decline. Recent studies indicate that T lymphocytes and eosinophils are important determinants of disease stability in COPD. We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease.Methods: Baseline lung lavage and plasma samples were collected from COPD subjects with moderately severe airway obstruction and emphysematous changes on chest CT. The study participants were former smokers who had not had a disease exacerbation within the past six months or used steroids within the past two months. Those subjects who demonstrated stable disease over the following six months (ΔFEV1 % predicted = 4.7 ± 7.2; N = 34) were retrospectively compared with study participants who experienced a rapid decline in lung function (ΔFEV1 % predicted = -16.0 ± 6.0; N = 16) during the same time period and with normal controls (N = 11). Plasma and lung lavage cytokines were measured from clinical samples using the Luminex multiplex kit which enabled the simultaneous measurement of several T cell and eosinophil related cytokines.Results and Discussion: Stable COPD participants had significantly higher plasma IL-2 levels compared to participants with rapidly progressive COPD (p = 0.04). In contrast, plasma eotaxin-1 levels were significantly lower in stable COPD subjects compared to normal controls (p <0.03). In addition, lung lavage eotaxin-1 levels were significantly higher in rapidly progressive COPD participants compared to both normal controls (p <0.02) and stable COPD participants (p <0.05).Conclusion: These findings indicate that IL-2 and eotaxin-1 levels may be important markers of disease stability in advanced emphysema patients. Prospective studies will need to confirm whether measuring IL-2 or eotaxin-1 can identify patients at risk for rapid disease progression.

AB - Background: The major marker utilized to monitor COPD patients is forced expiratory volume in one second (FEV1). However, asingle measurement of FEV1 cannot reliably predict subsequent decline. Recent studies indicate that T lymphocytes and eosinophils are important determinants of disease stability in COPD. We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease.Methods: Baseline lung lavage and plasma samples were collected from COPD subjects with moderately severe airway obstruction and emphysematous changes on chest CT. The study participants were former smokers who had not had a disease exacerbation within the past six months or used steroids within the past two months. Those subjects who demonstrated stable disease over the following six months (ΔFEV1 % predicted = 4.7 ± 7.2; N = 34) were retrospectively compared with study participants who experienced a rapid decline in lung function (ΔFEV1 % predicted = -16.0 ± 6.0; N = 16) during the same time period and with normal controls (N = 11). Plasma and lung lavage cytokines were measured from clinical samples using the Luminex multiplex kit which enabled the simultaneous measurement of several T cell and eosinophil related cytokines.Results and Discussion: Stable COPD participants had significantly higher plasma IL-2 levels compared to participants with rapidly progressive COPD (p = 0.04). In contrast, plasma eotaxin-1 levels were significantly lower in stable COPD subjects compared to normal controls (p <0.03). In addition, lung lavage eotaxin-1 levels were significantly higher in rapidly progressive COPD participants compared to both normal controls (p <0.02) and stable COPD participants (p <0.05).Conclusion: These findings indicate that IL-2 and eotaxin-1 levels may be important markers of disease stability in advanced emphysema patients. Prospective studies will need to confirm whether measuring IL-2 or eotaxin-1 can identify patients at risk for rapid disease progression.

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