Abstract
Kinetic resolution of various α,α-difluoro-β- hydroxyketones was conducted by enantioselective hydrolysis of the corresponding acetates with lipase MY to afford optically active products. Both enantiomers of 3,3-difluoro-2-hydroxy-4-decanone were obtained in a highly enantioselective manner by screening enzymes and acyl groups.
Original language | English (US) |
---|---|
Pages (from-to) | 3181-3186 |
Number of pages | 6 |
Journal | Synthetic Communications |
Volume | 20 |
Issue number | 20 |
DOIs | |
State | Published - 1990 |
Externally published | Yes |
ASJC Scopus subject areas
- Organic Chemistry