Enzymic optical resolution of α,α-difluoro-β-hydroxyketones

Takashi Tsukamoto, Takashi Yamazaki, Tomoya Kitazume*

Research output: Contribution to journalArticlepeer-review


Kinetic resolution of various α,α-difluoro-β- hydroxyketones was conducted by enantioselective hydrolysis of the corresponding acetates with lipase MY to afford optically active products. Both enantiomers of 3,3-difluoro-2-hydroxy-4-decanone were obtained in a highly enantioselective manner by screening enzymes and acyl groups.

Original languageEnglish (US)
Pages (from-to)3181-3186
Number of pages6
JournalSynthetic Communications
Issue number20
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry


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