Enzymes that push DNA around

James L. Keck, James M. Berger

Research output: Contribution to journalShort survey


DNA topoisomerases are proteins that regulate DNA topology in cells through selective cycles of DNA cleavage, manipulation, and relegation. Two papers describe an ensemble of different protein conformations and nucleotide-protein complexes of Escherichia coli topoisomerase. These results lead to new insights about how this enzyme recognizes DNA and catalyzes supercoil relaxation.

Original languageEnglish (US)
Pages (from-to)900-902
Number of pages3
JournalNature structural biology
Issue number10
StatePublished - Oct 13 1999
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics

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