Enzymes that push DNA around

James L. Keck, James M Berger

Research output: Contribution to journalArticle

Abstract

DNA topoisomerases are proteins that regulate DNA topology in cells through selective cycles of DNA cleavage, manipulation, and relegation. Two papers describe an ensemble of different protein conformations and nucleotide-protein complexes of Escherichia coli topoisomerase. These results lead to new insights about how this enzyme recognizes DNA and catalyzes supercoil relaxation.

Original languageEnglish (US)
Pages (from-to)900-902
Number of pages3
JournalNature Structural Biology
Volume6
Issue number10
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

DNA Topoisomerases
DNA Cleavage
Protein Conformation
Escherichia coli Proteins
DNA
Enzymes
Proteins
Nucleotides
Escherichia coli
Conformations
Topology

ASJC Scopus subject areas

  • Biochemistry
  • Structural Biology
  • Genetics

Cite this

Enzymes that push DNA around. / Keck, James L.; Berger, James M.

In: Nature Structural Biology, Vol. 6, No. 10, 1999, p. 900-902.

Research output: Contribution to journalArticle

Keck, James L. ; Berger, James M. / Enzymes that push DNA around. In: Nature Structural Biology. 1999 ; Vol. 6, No. 10. pp. 900-902.
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