Enzyme-linked immunosorbent assay for measurement of serological response to respiratory syncytial virus infection

Linda S. Richardson, Robert H. Yolken, Robert B. Belshe, Ena Camargo, Hyun W. Kim, Robert M. Chanock

Research output: Contribution to journalArticlepeer-review

Abstract

An enzyme-linked immunosorbent assay was applied to the detection of serum antibodies against respiratory syncytial virus. The end points of the various sera tested in the assay were approximately 100 times higher than in the complement-fixation test and 2 to 4 times higher than in the plaque reduction test. In addition, the immunosorbent assay appeared to be more efficient than the plaque reduction and complement-fixation techniques for detecting a serological response in young infants (1 to 6 months old) with serious respiratory syncytial virus lower respiratory disease. The simplicity, sensitivity, and rapidity of the enzyme-linked immunosorbent assay make it a useful tool for immunological studies with respiratory syncytial virus.

Original languageEnglish (US)
Pages (from-to)660-664
Number of pages5
JournalUnknown Journal
Volume20
Issue number3
DOIs
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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