Enzyme-linked immunosorbent assay (ELISA) for the detection of antibody to cysticerci of Taenia solium

A. R. Diwan, M. Coker-Vann, P. Brown, D. B. Subianto, R. Yolken, R. Desowitz, A. Escobar, C. J. Gibbs, D. C. Gajdusek

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Abstract

An enzyme-linked immunosorbent assay (ELISA) for the detection of antibody to cysticerci of Taenia solium has been developed that employs a pork muscle antigen control for the cysticercus test antigen, somewhat improving the serological distinction between infected and uninfected subjects. Serum antibody to cysticercus was detected in 79% of classical neurocysticercosis patients from Mexico, and in 61% of a group of cysticercosis patients with an unusually rapid invasion of the central nervous system in an endemic focus of disease in Irian Jaya. Antibody was absent in a group of healthy American laboratory personnel, and in residents of a non-endemic region of Papua New Guinea. Additional tests on sera from patients with other parasitic diseases showed that cross-reactivity may occur in some patients with schistosomiasis, echinococcosis, and possibly angiostrongyliasis; however, these parasites are not known to cause human infection in Irian Jaya.

Original languageEnglish (US)
Pages (from-to)364-369
Number of pages6
JournalUnknown Journal
Volume31
Issue number2
DOIs
StatePublished - Jan 1 1982

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ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

Cite this

Diwan, A. R., Coker-Vann, M., Brown, P., Subianto, D. B., Yolken, R., Desowitz, R., Escobar, A., Gibbs, C. J., & Gajdusek, D. C. (1982). Enzyme-linked immunosorbent assay (ELISA) for the detection of antibody to cysticerci of Taenia solium. Unknown Journal, 31(2), 364-369. https://doi.org/10.4269/ajtmh.1982.31.364