Enzyme-linked immunosorbent assay (ELISA) for the detection of antibody to cysticerci of Taenia solium

A. R. Diwan, M. Coker-Vann, P. Brown, D. B. Subianto, R. Yolken, R. Desowitz, A. Escobar, C. J. Gibbs, D. C. Gajdusek

Research output: Contribution to journalArticlepeer-review

Abstract

An enzyme-linked immunosorbent assay (ELISA) for the detection of antibody to cysticerci of Taenia solium has been developed that employs a pork muscle antigen control for the cysticercus test antigen, somewhat improving the serological distinction between infected and uninfected subjects. Serum antibody to cysticercus was detected in 79% of classical neurocysticercosis patients from Mexico, and in 61% of a group of cysticercosis patients with an unusually rapid invasion of the central nervous system in an endemic focus of disease in Irian Jaya. Antibody was absent in a group of healthy American laboratory personnel, and in residents of a non-endemic region of Papua New Guinea. Additional tests on sera from patients with other parasitic diseases showed that cross-reactivity may occur in some patients with schistosomiasis, echinococcosis, and possibly angiostrongyliasis; however, these parasites are not known to cause human infection in Irian Jaya.

Original languageEnglish (US)
Pages (from-to)364-369
Number of pages6
JournalUnknown Journal
Volume31
Issue number2
DOIs
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Enzyme-linked immunosorbent assay (ELISA) for the detection of antibody to cysticerci of Taenia solium'. Together they form a unique fingerprint.

Cite this