Abstract
(Figure Presented) By covalently connecting taxol with a motif that is prone to self-assemble, we successfully generate the precursor (5a), the hydrogelator (5b), and hydrogel of a taxol derivative without compromising the cytotoxic activity of the taxol. This approach promises a general method to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself.
Original language | English (US) |
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Pages (from-to) | 13576-13577 |
Number of pages | 2 |
Journal | Journal of the American Chemical Society |
Volume | 131 |
Issue number | 38 |
DOIs | |
State | Published - Jan 1 2009 |
Externally published | Yes |
ASJC Scopus subject areas
- Catalysis
- General Chemistry
- Biochemistry
- Colloid and Surface Chemistry