Enzyme-instructed molecular self-assembly confers nanofibers and a supramolecular hydrogel of taxol derivative

Yuan Gao, Yi Kuang, Zu Feng Guo, Zhihong Guo, Isaac J. Krauss, Bing Xu

Research output: Contribution to journalArticlepeer-review

Abstract

(Figure Presented) By covalently connecting taxol with a motif that is prone to self-assemble, we successfully generate the precursor (5a), the hydrogelator (5b), and hydrogel of a taxol derivative without compromising the cytotoxic activity of the taxol. This approach promises a general method to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself.

Original languageEnglish (US)
Pages (from-to)13576-13577
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number38
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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