TY - JOUR
T1 - Enzyme activity of macrophage migration inhibitory factor toward oxidized catecholamines
AU - Matsunaga, Jun
AU - Sinha, Debasish
AU - Pannell, Lew
AU - Santist, Chie
AU - Solano, Francisco
AU - Wistow, Graeme J.
AU - Hearing, Vincent J.
PY - 1999/2/5
Y1 - 1999/2/5
N2 - Macrophage migration inhibitory factor (MIF) is a relatively small, 12.5-kDa protein that is structurally related to some isomerases and for which multiple immune and catalytic roles have been proposed. MIF is widely expressed in tissues with particularly high levels in neural tissues. Here we show that MIF is able to catalyze the conversion of 3,4- dihydroxyphenylaminechrome and norepinephrinechrome, toxic quinone products of the neurotransmitter catecholamines 3,4-dihydroxyphenylamine and norepinephrine, to indoledihydroxy derivatives that may serve as precursors to neuromelanin. This raises the possibility that MIF participates in a detoxification pathway for catecholamine products and could therefore have a protective role in neural tissues, which as in Parkinson's disease, may be subject to catecholamine-related cell death.
AB - Macrophage migration inhibitory factor (MIF) is a relatively small, 12.5-kDa protein that is structurally related to some isomerases and for which multiple immune and catalytic roles have been proposed. MIF is widely expressed in tissues with particularly high levels in neural tissues. Here we show that MIF is able to catalyze the conversion of 3,4- dihydroxyphenylaminechrome and norepinephrinechrome, toxic quinone products of the neurotransmitter catecholamines 3,4-dihydroxyphenylamine and norepinephrine, to indoledihydroxy derivatives that may serve as precursors to neuromelanin. This raises the possibility that MIF participates in a detoxification pathway for catecholamine products and could therefore have a protective role in neural tissues, which as in Parkinson's disease, may be subject to catecholamine-related cell death.
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U2 - 10.1074/jbc.274.6.3268
DO - 10.1074/jbc.274.6.3268
M3 - Article
C2 - 9920865
AN - SCOPUS:0033525123
SN - 0021-9258
VL - 274
SP - 3268
EP - 3271
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 6
ER -