Environmental factors in cardiovascular disease

Kristen E. Cosselman, Ana Navas Acien, Joel D. Kaufman

Research output: Contribution to journalArticle

Abstract

Environmental exposure is an important but underappreciated risk factor contributing to the development and severity of cardiovascular disease (CVD). The heart and vascular system are highly vulnerable to a number of environmental agents - ambient air pollution and the metals arsenic, cadmium, and lead are widespread and the most-extensively studied. Like traditional risk factors, such as smoking and diabetes mellitus, these exposures advance disease and mortality via augmentation or initiation of pathophysiological processes associated with CVD, including blood-pressure control, carbohydrate and lipid metabolism, vascular function, and atherogenesis. Although residence in highly polluted areas is associated with high levels of cardiovascular risk, adverse effects on cardiovascular health also occur at exposure levels below current regulatory standards. Considering the widespread prevalence of exposure, even modest contributions to CVD risk can have a substantial effect on population health. Evidence-based clinical and public-health strategies aimed at reducing environmental exposures from current levels could substantially lower the burden of CVD-related death and disability worldwide.

Original languageEnglish (US)
Pages (from-to)627-642
Number of pages16
JournalNature Reviews Cardiology
Volume12
Issue number11
DOIs
StatePublished - Nov 1 2015

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Cardiovascular Diseases
Environmental Exposure
Blood Vessels
Air Pollution
Health
Carbohydrate Metabolism
Arsenic
Cadmium
Lipid Metabolism
Atherosclerosis
Diabetes Mellitus
Public Health
Smoking
Metals
Blood Pressure
Mortality
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cosselman, K. E., Navas Acien, A., & Kaufman, J. D. (2015). Environmental factors in cardiovascular disease. Nature Reviews Cardiology, 12(11), 627-642. https://doi.org/10.1038/nrcardio.2015.152

Environmental factors in cardiovascular disease. / Cosselman, Kristen E.; Navas Acien, Ana; Kaufman, Joel D.

In: Nature Reviews Cardiology, Vol. 12, No. 11, 01.11.2015, p. 627-642.

Research output: Contribution to journalArticle

Cosselman, KE, Navas Acien, A & Kaufman, JD 2015, 'Environmental factors in cardiovascular disease' Nature Reviews Cardiology, vol. 12, no. 11, pp. 627-642. https://doi.org/10.1038/nrcardio.2015.152
Cosselman, Kristen E. ; Navas Acien, Ana ; Kaufman, Joel D. / Environmental factors in cardiovascular disease. In: Nature Reviews Cardiology. 2015 ; Vol. 12, No. 11. pp. 627-642.
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