TY - JOUR
T1 - Environmental estrogens and breast cancer risk
AU - Davidson, Nancy E.
PY - 1998
Y1 - 1998
N2 - Controversy exists over the role that environmental estrogens, such as pesticides or polychlorinated biphenyls (PCBs), might play as risk factors for breast cancer. Several laboratory studies have suggested that these chemicals function as weak estrogens, binding to the estrogen receptor and inducing various measures of estrogen response. However, epidemiologic studies assessing the link between exposure to pesticides or PCBs and breast cancer have generally not shown enhanced breast cancer risk with higher levels of xenoestrogen exposure. These findings heighten our uncertainty about the relevance of the preclinical findings to human breast cancer risk.
AB - Controversy exists over the role that environmental estrogens, such as pesticides or polychlorinated biphenyls (PCBs), might play as risk factors for breast cancer. Several laboratory studies have suggested that these chemicals function as weak estrogens, binding to the estrogen receptor and inducing various measures of estrogen response. However, epidemiologic studies assessing the link between exposure to pesticides or PCBs and breast cancer have generally not shown enhanced breast cancer risk with higher levels of xenoestrogen exposure. These findings heighten our uncertainty about the relevance of the preclinical findings to human breast cancer risk.
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U2 - 10.1097/00001622-199809000-00018
DO - 10.1097/00001622-199809000-00018
M3 - Short survey
C2 - 9800120
AN - SCOPUS:0031762212
SN - 1040-8746
VL - 10
SP - 475
EP - 478
JO - Current opinion in oncology
JF - Current opinion in oncology
IS - 5
ER -