Environmental covariates: Effects on the power of sib-pair linkage methods

Diptasri M. Mandal; Alexa J.M. Sorant; Elizabeth W. Pugh; Sherry E. Marcus; Alison P. Klein; Rasika A. Mathias; Jennifer O'Neill; Loyrirk F. Temiyakarn; Alexander F. Wilson; Joan E. Bailey-Wilson

doi:10.1002/gepi.13701707105

Environmental covariates: Effects on the power of sib-pair linkage methods

Diptasri M. Mandal, Alexa J.M. Sorant, Elizabeth W. Pugh, Sherry E. Marcus, Alison P. Klein, Rasika A. Mathias, Jennifer O'Neill, Loyrirk F. Temiyakarn, Alexander F. Wilson, Joan E. Bailey-Wilson

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The effect of inclusion of environmental risk factors on the power of sib-pair linkage methods was tested for a qualitative trait. It was found that inclusion of an environmental variable did not increase the power of the Haseman-Elston (H-E) sib-pair nonparametric linkage analysis test. However, a significant increase in power was observed for both the H-E and affected-sib- pair tests, even in small samples, when persons unexposed to the environmental risk factor were coded as unknown.

Original language	English (US)
Pages (from-to)	S643-S648
Journal	Genetic epidemiology
Volume	17
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1002/gepi.13701707105
State	Published - 1999

Keywords

Affected-sib-pair test
Complex traits
Sib-pair linkage test

ASJC Scopus subject areas

Epidemiology
Genetics(clinical)

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10.1002/gepi.13701707105

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title = "Environmental covariates: Effects on the power of sib-pair linkage methods",

abstract = "The effect of inclusion of environmental risk factors on the power of sib-pair linkage methods was tested for a qualitative trait. It was found that inclusion of an environmental variable did not increase the power of the Haseman-Elston (H-E) sib-pair nonparametric linkage analysis test. However, a significant increase in power was observed for both the H-E and affected-sib- pair tests, even in small samples, when persons unexposed to the environmental risk factor were coded as unknown.",

keywords = "Affected-sib-pair test, Complex traits, Sib-pair linkage test",

author = "Mandal, {Diptasri M.} and Sorant, {Alexa J.M.} and Pugh, {Elizabeth W.} and Marcus, {Sherry E.} and Klein, {Alison P.} and Mathias, {Rasika A.} and Jennifer O'Neill and Temiyakarn, {Loyrirk F.} and Wilson, {Alexander F.} and Bailey-Wilson, {Joan E.}",

year = "1999",

doi = "10.1002/gepi.13701707105",

language = "English (US)",

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TY - JOUR

T1 - Environmental covariates

T2 - Effects on the power of sib-pair linkage methods

AU - Mandal, Diptasri M.

AU - Sorant, Alexa J.M.

AU - Pugh, Elizabeth W.

AU - Marcus, Sherry E.

AU - Klein, Alison P.

AU - Mathias, Rasika A.

AU - O'Neill, Jennifer

AU - Temiyakarn, Loyrirk F.

AU - Wilson, Alexander F.

AU - Bailey-Wilson, Joan E.

PY - 1999

Y1 - 1999

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AB - The effect of inclusion of environmental risk factors on the power of sib-pair linkage methods was tested for a qualitative trait. It was found that inclusion of an environmental variable did not increase the power of the Haseman-Elston (H-E) sib-pair nonparametric linkage analysis test. However, a significant increase in power was observed for both the H-E and affected-sib- pair tests, even in small samples, when persons unexposed to the environmental risk factor were coded as unknown.

KW - Affected-sib-pair test

KW - Complex traits

KW - Sib-pair linkage test

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Environmental covariates: Effects on the power of sib-pair linkage methods

Abstract

Keywords

ASJC Scopus subject areas

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