Environmental covariates: Effects on the power of sib-pair linkage methods

Diptasri M. Mandal, Alexa J.M. Sorant, Elizabeth W. Pugh, Sherry E. Marcus, Alison P. Klein, Rasika A. Mathias, Jennifer O'Neill, Loyrirk F. Temiyakarn, Alexander F. Wilson, Joan E. Bailey-Wilson

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The effect of inclusion of environmental risk factors on the power of sib-pair linkage methods was tested for a qualitative trait. It was found that inclusion of an environmental variable did not increase the power of the Haseman-Elston (H-E) sib-pair nonparametric linkage analysis test. However, a significant increase in power was observed for both the H-E and affected-sib- pair tests, even in small samples, when persons unexposed to the environmental risk factor were coded as unknown.

Original languageEnglish (US)
Pages (from-to)S643-S648
JournalGenetic epidemiology
Issue numberSUPPL. 1
StatePublished - 1999


  • Affected-sib-pair test
  • Complex traits
  • Sib-pair linkage test

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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