Environmental and epigenetic effects upon preimplantation embryo metabolism and development

Rebecca J. Chason, John Csokmay, James H. Segars, Alan H. DeCherney, D. Randall Armant

Research output: Contribution to journalReview articlepeer-review


In vitro fertilization has provided a unique window into the metabolic processes that drive embryonic growth and development from a fertilized ovum to a competent blastocyst. Post-fertilization development is dependent upon a dramatic reshuffling of the parental genomes during meiosis, as well as epigenetic changes that provide a new and autonomous set of instructions to guide cellular differentiation both in the embryo and beyond. Although early literature focused simply on the substrates and culture conditions required for progress through embryonic development, more recent insights lead us to suggest that the surrounding environment can alter the epigenome, which can, in turn, impact upon embryonic metabolism and developmental competence.

Original languageEnglish (US)
Pages (from-to)412-420
Number of pages9
JournalTrends in Endocrinology and Metabolism
Issue number10
StatePublished - Oct 2011
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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