Enucleation Versus Plaque Irradiation for Choroidal Melanoma

Bradley R. Straatsma, Stuart L. Fine, John D. Earle, Barbara S. Hawkins, Marie Diener-West, Jack A. McLaughlin, Matthew D. Davis, Thomas E. Davis, James Eltringham, Frederick L. Ferris, J. Donald M. Gass, Lael C. Gatewood, Robert J. Levine, Robert W. Makuch

Research output: Contribution to journalArticle

Abstract

The Collaborative Ocular Melanoma Study (COMS) is an international, multicenter-controlled study. The organization includes an Executive Committee, Steering Committee, 6 Central Units, 32 Clinical Centers, and a Data and Safety Monitoring Committee. Scientifically, the COMS consists of (1) a randomized trial of patients with medium choroidal melanoma treated with enucleation versus iodine-125 plaque irradiation, (2) a randomized trial of patients with large choroidal melanoma treated with enucleation versus preenucleation external beam irradiation and enucleation, and (3) a prospective observational study of patients with small choroidal melanoma to determine whether a randomized trial of treatment is appropriate. In design and conduct of the COMS, special consideration is given to biostatistics and sample size considerations, iodine-125 plaque irradiation of choroidal melanoma, and coordinated ocular melanoma research. Recruitment is in progress. However, the pool of eligible patients is limited and the COMS needs the continued support and cooperation of ophthalmologists throughout the United States and Canada.

Original languageEnglish (US)
Pages (from-to)1000-1004
Number of pages5
JournalOphthalmology
Volume95
Issue number7
DOIs
StatePublished - 1988

Keywords

  • choroidal melanoma
  • cobalt-60
  • enucleation
  • iodine-125
  • iridium-192
  • melanoma
  • plaque irradiation

ASJC Scopus subject areas

  • Ophthalmology

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  • Cite this

    Straatsma, B. R., Fine, S. L., Earle, J. D., Hawkins, B. S., Diener-West, M., A. McLaughlin, J., Davis, M. D., Davis, T. E., Eltringham, J., Ferris, F. L., M. Gass, J. D., Gatewood, L. C., Levine, R. J., & Makuch, R. W. (1988). Enucleation Versus Plaque Irradiation for Choroidal Melanoma. Ophthalmology, 95(7), 1000-1004. https://doi.org/10.1016/S0161-6420(88)33086-1