Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry

for the, Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction Autopsy findings have shown the entorhinal cortex and transentorhinal cortex are among the earliest sites of accumulation of pathology in patients developing Alzheimer's disease. Methods Here, we study this region in subjects with mild cognitive impairment (n = 36) and in control subjects (n = 16). The cortical areas are manually segmented, and local volume and shape changes are quantified using diffeomorphometry, including a novel mapping procedure that reduces variability in anatomic definitions over time. Results We find significant thickness and volume changes localized to the transentorhinal cortex through high field strength atlasing. Discussion This demonstrates that in vivo neuroimaging biomarkers can detect these early changes among subjects with mild cognitive impairment.

Original languageEnglish (US)
Pages (from-to)41-50
Number of pages10
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume9
DOIs
StatePublished - 2017

Keywords

  • Braak staging
  • Diffeomorphometry
  • Entorhinal cortex
  • Longitudinal analysis
  • Mild cognitive impairment
  • Shape analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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