Enterovirus D68 infection in children with acute flaccid Myelitis, Colorado, USA, 2014

Negar Aliabadi, Kevin Messacar, Daniel M. Pastula, Christine C. Robinson, Eyal Leshem, James J. Sejvar, W. Allan Nix, M. Steven Oberste, Daniel R. Feikin, Samuel R. Dominguez

Research output: Contribution to journalArticlepeer-review

Abstract

During August 8, 2014-October 14, 2014, a total of 11 children with acute flaccid myelitis and distinctive neuroimaging changes were identified near Denver, Colorado, USA. A respiratory prodrome was experienced by 10, and nasopharyngeal specimens were positive for enterovirus D68 (EV-D68) for 4. To determine whether an association exists between EV-D68 infection and acute flaccid myelitis, we conducted a retrospective case-control study comparing these patients with 2 groups of outpatient control children (1 group tested for acute respiratory illness and 1 for Bordetella pertussis infection). Adjusted analyses indicated that, for children with acute flaccid myelitis, the odds of having EV-D68 infection were 10.3 times greater than for those tested for acute respiratory infection and 4.5 times greater than for those tested for B. pertussis infection. No statistical association was seen between acute flaccid myelitis and non-EV-D68 enterovirus or rhinovirus infection. These findings support an association between EV-D68 infection and acute flaccid myelitis.

Original languageEnglish (US)
Pages (from-to)1387-1394
Number of pages8
JournalEmerging infectious diseases
Volume22
Issue number8
DOIs
StatePublished - Aug 2016

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Enterovirus D68 infection in children with acute flaccid Myelitis, Colorado, USA, 2014'. Together they form a unique fingerprint.

Cite this