Enterotoxigenic Escherichia coli diarrhea of travelers: A prospective study of American Peace Corps Volunteers

David Allen Sack, D. C. Kaminsky, R. B. Sack, I. A. Wamola, F. Orskov, I. Orskov, R. C. Slack, R. R. Arthur, A. Z. Kapikian

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Travelers' diarrhea was studied prospectively in a group of 39 American Peace Corps Volunteers (PCVs) during their first five weeks in Kenya. Twenty-seven developed diarrheal disease and 12 remained well. Multiple episodes were documented in 11 of the symptomatic volunteers. Enterotoxigenic Escherichia coli of many serotypes producing heat-labile and/or heat-stable enterotoxin were isolated from 17 of the 27 volunteers with diarrhea and from 1 of the 12 well volunteers. The enterotoxigenic E. coli were more likely to be antibiotic sensitive than the nonenterotoxigenic E. coli. A serum antibody rise to the heat-labile toxin (LT) was detected in six symptomatic volunteers, five of whom had a positive culture for LT-producing E. coli, and from one asymptomatic, culture negative volunteer. Salmonella cubana was isolated from two volunteers, and three volunteers had serologic evidence of infection with human reovirus-like (rotavirus) agent. This study confirms the role of enterotoxigenic E. coli as a major cause of travelers' diarrhea and suggests that the disease is similar in widely separated geographic areas.

Original languageEnglish (US)
Title of host publicationJohns Hopkins Medical Journal
Pages63-70
Number of pages8
Volume141
Edition2
StatePublished - 1977

Fingerprint

Peace Corps
Enterotoxigenic Escherichia coli
Volunteers
Diarrhea
Prospective Studies
Hot Temperature
Escherichia coli
Rotavirus
Kenya
Enterotoxins
Salmonella

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sack, D. A., Kaminsky, D. C., Sack, R. B., Wamola, I. A., Orskov, F., Orskov, I., ... Kapikian, A. Z. (1977). Enterotoxigenic Escherichia coli diarrhea of travelers: A prospective study of American Peace Corps Volunteers. In Johns Hopkins Medical Journal (2 ed., Vol. 141, pp. 63-70)

Enterotoxigenic Escherichia coli diarrhea of travelers : A prospective study of American Peace Corps Volunteers. / Sack, David Allen; Kaminsky, D. C.; Sack, R. B.; Wamola, I. A.; Orskov, F.; Orskov, I.; Slack, R. C.; Arthur, R. R.; Kapikian, A. Z.

Johns Hopkins Medical Journal. Vol. 141 2. ed. 1977. p. 63-70.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sack, DA, Kaminsky, DC, Sack, RB, Wamola, IA, Orskov, F, Orskov, I, Slack, RC, Arthur, RR & Kapikian, AZ 1977, Enterotoxigenic Escherichia coli diarrhea of travelers: A prospective study of American Peace Corps Volunteers. in Johns Hopkins Medical Journal. 2 edn, vol. 141, pp. 63-70.
Sack DA, Kaminsky DC, Sack RB, Wamola IA, Orskov F, Orskov I et al. Enterotoxigenic Escherichia coli diarrhea of travelers: A prospective study of American Peace Corps Volunteers. In Johns Hopkins Medical Journal. 2 ed. Vol. 141. 1977. p. 63-70
Sack, David Allen ; Kaminsky, D. C. ; Sack, R. B. ; Wamola, I. A. ; Orskov, F. ; Orskov, I. ; Slack, R. C. ; Arthur, R. R. ; Kapikian, A. Z. / Enterotoxigenic Escherichia coli diarrhea of travelers : A prospective study of American Peace Corps Volunteers. Johns Hopkins Medical Journal. Vol. 141 2. ed. 1977. pp. 63-70
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