Enteropathogens Associated with Acute and Persistent Diarrhea in Bangladeshi Children <5 Years of Age

Abdullah H. Baqui, R. Bradley Sack, Robert E. Black, Khaleda Haider, Anowar Hossain, A. R.M. Abdul Alim, M. Yunus, H. R. Chowdhury, A. K. Siddique

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Abstract

A longitudinal study of diarrhea was carried out from May 1988 to April 1989 by household surveillance of 705 children <5 years old in rural Bangladesh. Stool samples were examined for enteric pathogens at the beginning of each diarrheal episode. For persistent episodes, stool examination was repeated on days 15-17 of the illness. For each case of persistent diarrhea, stool samples from age-matched acute diarrheal and healthy controls were examined. Compared with healthy controls, cases of diarrhea were associated with Shigella species (P =.07) and rotavirus (P <.05). Diffusely adherent Escherichia coli (P <.05) and Cryptosporidia (P =.07) were the only enteropathogens associated with persistent diarrhea in comparison with acute diarrhea. No more than 15% of children had the same class of pathogen identified from stool on both days 1-3 and days 15-17, indicating that persistent infection was uncommon. However, a different entero- pathogen was frequently found on days 15-17, suggesting that sequential infection may be a cause of persistent diarrhea.

Original languageEnglish (US)
Pages (from-to)792-796
Number of pages5
JournalJournal of Infectious Diseases
Volume166
Issue number4
DOIs
StatePublished - Oct 1992

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Baqui, A. H., Bradley Sack, R., Black, R. E., Haider, K., Hossain, A., Abdul Alim, A. R. M., Yunus, M., Chowdhury, H. R., & Siddique, A. K. (1992). Enteropathogens Associated with Acute and Persistent Diarrhea in Bangladeshi Children <5 Years of Age. Journal of Infectious Diseases, 166(4), 792-796. https://doi.org/10.1093/infdis/166.4.792