Enteroendocrine Connections in Congenital Isolated GH Deficiency Due to a GHRH Receptor Gene Mutation

Alécia A. Oliveira-Santos, Roberto Salvatori, Monica C. Nogueira, Ana C. Bueno, Cynthia S. Barros-Oliveira, Ângela C.G.B. Leal, Cindi G. Marinho, Nayra P. Damascena, Djane A. Oliveira, Manuela A. Melo, Carla R.P. Oliveira, Flavia O. da Costa, Jéssica S.S. Dos Santos, Paula F.C. Santos, Viviane C. Campos, Elenilde G. Santos, Enaldo V. Melo, Meirielly L.A. Barbosa, Ivina E.S. Rocha, Margaret de CastroManuel H. Aguiar-Oliveira

Research output: Contribution to journalArticle

Abstract

CONTEXT: GH and IGF-1 are crucial for attainment of normal body size and regulation of food intake, nutrient storage, and insulin sensitivity. Enteroendocrine connections exist between the GH-IGF-1 axis and insulin, ghrelin, and glucagon-like peptide 1 (GLP-1). The status of these connections in GH deficiency (GHD) is unknown. OBJECTIVE: To study the enteroendocrine connections before and after a standard meal test in a homogeneous population of adults with congenital untreated isolated GHD (IGHD) due to a mutation in the GHRH receptor gene. DESIGN: In a cross-sectional study of 20 individuals with IGHD and 20 control subjects, we measured glucose, insulin, ghrelin, and GLP-1 before and 30, 60, 120, and 180 minutes after a standardized test meal. Homeostasis model assessment index of insulin resistance (HOMA-IR) and homeostasis model assessment (HOMA)-β were calculated. Participants scored feelings of hunger, fullness, and prospective food consumption on a visual analog scale. MAIN OUTCOME MEASURES: Area under the curve (AUC) values of glucose, insulin, ghrelin, GLP-1, hunger, fullness, and prospective food consumption. RESULTS: Fasting HOMA-IR and HOMA-β were lower in individuals with IGHD than in control subjects (P = 0.002 and P = 0.023, respectively). AUC was higher for hunger (P < 0.0001), glucose (P = 0.0157), ghrelin (P < 0.0001), and GLP-1 (P < 0.0001) and smaller for fullness (P < 0.0001) in individuals with IGHD compared with control subjects. There was no difference in AUC for prospective food consumption or insulin. CONCLUSIONS: Untreated IGHD is associated with increased GLP-1 secretion and reduced postprandial ghrelin and hunger attenuation in response to a mixed meal. These enteroendocrine connections can result in a favorable outcome in terms of environmental adaptation and guaranteeing appropriate food intake and can confer metabolic benefits.

Original languageEnglish (US)
Pages (from-to)2777-2784
Number of pages8
JournalThe Journal of clinical endocrinology and metabolism
Volume104
Issue number7
DOIs
StatePublished - Jul 1 2019
Externally publishedYes

Fingerprint

Pituitary Dwarfism
Ghrelin
Glucagon-Like Peptide 1
Hunger
Genes
Insulin
Homeostasis
Mutation
Area Under Curve
Meals
Insulin Resistance
Food
Insulin-Like Growth Factor I
Glucose
Appetite Regulation
Body Size
Visual Analog Scale
Fasting
Emotions
Cross-Sectional Studies

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Oliveira-Santos, A. A., Salvatori, R., Nogueira, M. C., Bueno, A. C., Barros-Oliveira, C. S., Leal, Â. C. G. B., ... Aguiar-Oliveira, M. H. (2019). Enteroendocrine Connections in Congenital Isolated GH Deficiency Due to a GHRH Receptor Gene Mutation. The Journal of clinical endocrinology and metabolism, 104(7), 2777-2784. https://doi.org/10.1210/jc.2019-00094

Enteroendocrine Connections in Congenital Isolated GH Deficiency Due to a GHRH Receptor Gene Mutation. / Oliveira-Santos, Alécia A.; Salvatori, Roberto; Nogueira, Monica C.; Bueno, Ana C.; Barros-Oliveira, Cynthia S.; Leal, Ângela C.G.B.; Marinho, Cindi G.; Damascena, Nayra P.; Oliveira, Djane A.; Melo, Manuela A.; Oliveira, Carla R.P.; da Costa, Flavia O.; Dos Santos, Jéssica S.S.; Santos, Paula F.C.; Campos, Viviane C.; Santos, Elenilde G.; Melo, Enaldo V.; Barbosa, Meirielly L.A.; Rocha, Ivina E.S.; de Castro, Margaret; Aguiar-Oliveira, Manuel H.

In: The Journal of clinical endocrinology and metabolism, Vol. 104, No. 7, 01.07.2019, p. 2777-2784.

Research output: Contribution to journalArticle

Oliveira-Santos, AA, Salvatori, R, Nogueira, MC, Bueno, AC, Barros-Oliveira, CS, Leal, ÂCGB, Marinho, CG, Damascena, NP, Oliveira, DA, Melo, MA, Oliveira, CRP, da Costa, FO, Dos Santos, JSS, Santos, PFC, Campos, VC, Santos, EG, Melo, EV, Barbosa, MLA, Rocha, IES, de Castro, M & Aguiar-Oliveira, MH 2019, 'Enteroendocrine Connections in Congenital Isolated GH Deficiency Due to a GHRH Receptor Gene Mutation', The Journal of clinical endocrinology and metabolism, vol. 104, no. 7, pp. 2777-2784. https://doi.org/10.1210/jc.2019-00094
Oliveira-Santos, Alécia A. ; Salvatori, Roberto ; Nogueira, Monica C. ; Bueno, Ana C. ; Barros-Oliveira, Cynthia S. ; Leal, Ângela C.G.B. ; Marinho, Cindi G. ; Damascena, Nayra P. ; Oliveira, Djane A. ; Melo, Manuela A. ; Oliveira, Carla R.P. ; da Costa, Flavia O. ; Dos Santos, Jéssica S.S. ; Santos, Paula F.C. ; Campos, Viviane C. ; Santos, Elenilde G. ; Melo, Enaldo V. ; Barbosa, Meirielly L.A. ; Rocha, Ivina E.S. ; de Castro, Margaret ; Aguiar-Oliveira, Manuel H. / Enteroendocrine Connections in Congenital Isolated GH Deficiency Due to a GHRH Receptor Gene Mutation. In: The Journal of clinical endocrinology and metabolism. 2019 ; Vol. 104, No. 7. pp. 2777-2784.
@article{38c9dc0a101e4ff59f8063c4870e4ff3,
title = "Enteroendocrine Connections in Congenital Isolated GH Deficiency Due to a GHRH Receptor Gene Mutation",
abstract = "CONTEXT: GH and IGF-1 are crucial for attainment of normal body size and regulation of food intake, nutrient storage, and insulin sensitivity. Enteroendocrine connections exist between the GH-IGF-1 axis and insulin, ghrelin, and glucagon-like peptide 1 (GLP-1). The status of these connections in GH deficiency (GHD) is unknown. OBJECTIVE: To study the enteroendocrine connections before and after a standard meal test in a homogeneous population of adults with congenital untreated isolated GHD (IGHD) due to a mutation in the GHRH receptor gene. DESIGN: In a cross-sectional study of 20 individuals with IGHD and 20 control subjects, we measured glucose, insulin, ghrelin, and GLP-1 before and 30, 60, 120, and 180 minutes after a standardized test meal. Homeostasis model assessment index of insulin resistance (HOMA-IR) and homeostasis model assessment (HOMA)-β were calculated. Participants scored feelings of hunger, fullness, and prospective food consumption on a visual analog scale. MAIN OUTCOME MEASURES: Area under the curve (AUC) values of glucose, insulin, ghrelin, GLP-1, hunger, fullness, and prospective food consumption. RESULTS: Fasting HOMA-IR and HOMA-β were lower in individuals with IGHD than in control subjects (P = 0.002 and P = 0.023, respectively). AUC was higher for hunger (P < 0.0001), glucose (P = 0.0157), ghrelin (P < 0.0001), and GLP-1 (P < 0.0001) and smaller for fullness (P < 0.0001) in individuals with IGHD compared with control subjects. There was no difference in AUC for prospective food consumption or insulin. CONCLUSIONS: Untreated IGHD is associated with increased GLP-1 secretion and reduced postprandial ghrelin and hunger attenuation in response to a mixed meal. These enteroendocrine connections can result in a favorable outcome in terms of environmental adaptation and guaranteeing appropriate food intake and can confer metabolic benefits.",
author = "Oliveira-Santos, {Al{\'e}cia A.} and Roberto Salvatori and Nogueira, {Monica C.} and Bueno, {Ana C.} and Barros-Oliveira, {Cynthia S.} and Leal, {{\^A}ngela C.G.B.} and Marinho, {Cindi G.} and Damascena, {Nayra P.} and Oliveira, {Djane A.} and Melo, {Manuela A.} and Oliveira, {Carla R.P.} and {da Costa}, {Flavia O.} and {Dos Santos}, {J{\'e}ssica S.S.} and Santos, {Paula F.C.} and Campos, {Viviane C.} and Santos, {Elenilde G.} and Melo, {Enaldo V.} and Barbosa, {Meirielly L.A.} and Rocha, {Ivina E.S.} and {de Castro}, Margaret and Aguiar-Oliveira, {Manuel H.}",
year = "2019",
month = "7",
day = "1",
doi = "10.1210/jc.2019-00094",
language = "English (US)",
volume = "104",
pages = "2777--2784",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "7",

}

TY - JOUR

T1 - Enteroendocrine Connections in Congenital Isolated GH Deficiency Due to a GHRH Receptor Gene Mutation

AU - Oliveira-Santos, Alécia A.

AU - Salvatori, Roberto

AU - Nogueira, Monica C.

AU - Bueno, Ana C.

AU - Barros-Oliveira, Cynthia S.

AU - Leal, Ângela C.G.B.

AU - Marinho, Cindi G.

AU - Damascena, Nayra P.

AU - Oliveira, Djane A.

AU - Melo, Manuela A.

AU - Oliveira, Carla R.P.

AU - da Costa, Flavia O.

AU - Dos Santos, Jéssica S.S.

AU - Santos, Paula F.C.

AU - Campos, Viviane C.

AU - Santos, Elenilde G.

AU - Melo, Enaldo V.

AU - Barbosa, Meirielly L.A.

AU - Rocha, Ivina E.S.

AU - de Castro, Margaret

AU - Aguiar-Oliveira, Manuel H.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - CONTEXT: GH and IGF-1 are crucial for attainment of normal body size and regulation of food intake, nutrient storage, and insulin sensitivity. Enteroendocrine connections exist between the GH-IGF-1 axis and insulin, ghrelin, and glucagon-like peptide 1 (GLP-1). The status of these connections in GH deficiency (GHD) is unknown. OBJECTIVE: To study the enteroendocrine connections before and after a standard meal test in a homogeneous population of adults with congenital untreated isolated GHD (IGHD) due to a mutation in the GHRH receptor gene. DESIGN: In a cross-sectional study of 20 individuals with IGHD and 20 control subjects, we measured glucose, insulin, ghrelin, and GLP-1 before and 30, 60, 120, and 180 minutes after a standardized test meal. Homeostasis model assessment index of insulin resistance (HOMA-IR) and homeostasis model assessment (HOMA)-β were calculated. Participants scored feelings of hunger, fullness, and prospective food consumption on a visual analog scale. MAIN OUTCOME MEASURES: Area under the curve (AUC) values of glucose, insulin, ghrelin, GLP-1, hunger, fullness, and prospective food consumption. RESULTS: Fasting HOMA-IR and HOMA-β were lower in individuals with IGHD than in control subjects (P = 0.002 and P = 0.023, respectively). AUC was higher for hunger (P < 0.0001), glucose (P = 0.0157), ghrelin (P < 0.0001), and GLP-1 (P < 0.0001) and smaller for fullness (P < 0.0001) in individuals with IGHD compared with control subjects. There was no difference in AUC for prospective food consumption or insulin. CONCLUSIONS: Untreated IGHD is associated with increased GLP-1 secretion and reduced postprandial ghrelin and hunger attenuation in response to a mixed meal. These enteroendocrine connections can result in a favorable outcome in terms of environmental adaptation and guaranteeing appropriate food intake and can confer metabolic benefits.

AB - CONTEXT: GH and IGF-1 are crucial for attainment of normal body size and regulation of food intake, nutrient storage, and insulin sensitivity. Enteroendocrine connections exist between the GH-IGF-1 axis and insulin, ghrelin, and glucagon-like peptide 1 (GLP-1). The status of these connections in GH deficiency (GHD) is unknown. OBJECTIVE: To study the enteroendocrine connections before and after a standard meal test in a homogeneous population of adults with congenital untreated isolated GHD (IGHD) due to a mutation in the GHRH receptor gene. DESIGN: In a cross-sectional study of 20 individuals with IGHD and 20 control subjects, we measured glucose, insulin, ghrelin, and GLP-1 before and 30, 60, 120, and 180 minutes after a standardized test meal. Homeostasis model assessment index of insulin resistance (HOMA-IR) and homeostasis model assessment (HOMA)-β were calculated. Participants scored feelings of hunger, fullness, and prospective food consumption on a visual analog scale. MAIN OUTCOME MEASURES: Area under the curve (AUC) values of glucose, insulin, ghrelin, GLP-1, hunger, fullness, and prospective food consumption. RESULTS: Fasting HOMA-IR and HOMA-β were lower in individuals with IGHD than in control subjects (P = 0.002 and P = 0.023, respectively). AUC was higher for hunger (P < 0.0001), glucose (P = 0.0157), ghrelin (P < 0.0001), and GLP-1 (P < 0.0001) and smaller for fullness (P < 0.0001) in individuals with IGHD compared with control subjects. There was no difference in AUC for prospective food consumption or insulin. CONCLUSIONS: Untreated IGHD is associated with increased GLP-1 secretion and reduced postprandial ghrelin and hunger attenuation in response to a mixed meal. These enteroendocrine connections can result in a favorable outcome in terms of environmental adaptation and guaranteeing appropriate food intake and can confer metabolic benefits.

UR - http://www.scopus.com/inward/record.url?scp=85066870407&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066870407&partnerID=8YFLogxK

U2 - 10.1210/jc.2019-00094

DO - 10.1210/jc.2019-00094

M3 - Article

C2 - 30860584

AN - SCOPUS:85066870407

VL - 104

SP - 2777

EP - 2784

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 7

ER -