Enteroendocrine Connections in Congenital Isolated GH Deficiency Due to a GHRH Receptor Gene Mutation

Alecia A. Oliveira-Santos, Roberto Salvatori, Monica C. Nogueira, Ana C. Bueno, Cynthia S. Barros-Oliveira, Ângela C.G.B. Leal, Cindi G. Marinho, Nayra P. Damascena, Djane A. Oliveira, Manuela A. Melo, Carla R.P. Oliveira, Flavia O. Da Costa, Jinssica S.S. Dos Santos, Paula F.C. Santos, Viviane C. Campos, Elenilde G. Santos, Enaldo V. Melo, Meirielly L.A. Barbosa, Ivina E.S. Rocha, Margaret De CastroManuel H. Aguiar-Oliveira

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

GH and IGF-1 are crucial for attainment of normal body size and regulation of food intake, nutrient storage, and insulin sensitivity. Enteroendocrine connections exist between the GH-IGF-1 axis and insulin, ghrelin, and glucagon-like peptide 1 (GLP-1). The status of these connections in GH deficiency (GHD) is unknown. Objective: To study the enteroendocrine connections before and after a standard meal test in a homogeneous population of adults with congenital untreated isolated GHD (IGHD) due to a mutation in the GHRH receptor gene. Design: In a cross-sectional study of 20 individuals with IGHD and 20 control subjects, we measured glucose, insulin, ghrelin, and GLP-1 before and 30, 60, 120, and 180 minutes after a standardized test meal. Homeostasis model assessment index of insulin resistance (HOMA-IR) and homeostasis model assessment (HOMA)-b were calculated. Participants scored feelings of hunger, fullness, and prospective food consumption on a visual analog scale. Main Outcome Measures: Area under the curve (AUC) values of glucose, insulin, ghrelin, GLP-1, hunger, fullness, and prospective food consumption. Results: Fasting HOMA-IR and HOMA-b were lower in individuals with IGHD than in control subjects (P 5 0.002 and P 5 0.023, respectively). AUC was higher for hunger (P , 0.0001), glucose (P 5 0.0157), ghrelin (P , 0.0001), and GLP-1 (P , 0.0001) and smaller for fullness (P , 0.0001) in individuals with IGHD compared with control subjects. There was no difference in AUC for prospective food consumption or insulin.

Original languageEnglish (US)
Article numberjcem_201900094
Pages (from-to)2777-2784
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume104
Issue number7
DOIs
StatePublished - Mar 21 2019
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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