TY - JOUR
T1 - Enterococcal bacteremia in the surgical intensive care unit
T2 - Does vancomycin resistance affect mortality?
AU - Mainous, Mark R.
AU - Lipsett, Pamela A.
AU - O'Brien, Maureen
PY - 1997
Y1 - 1997
N2 - Objective: To determine the incidence and mortality rate associated with nosocomial bacteremia caused by vancomycin-resistant Enterococcus in a surgical intensive care unit. Design: A retrospective study. Setting: The surgical intensive care unit of a large university hospital tertiary referral center. Patients: All patients in the surgical intensive care unit with a documented nosocomial bacteremia between January 1, 1992, and December 31, 1994. Interventions: None. Main Outcome Measure: Mortality rate. Results: Of the 134 nosocomial bacteremic episodes, 30.6% involved enterococci; 24.4% of the enterococci were resistant to vancomycin. Patients with vancomycin-resistant enterococcal bacteremia had a significantly longer hospital stay (mean±SD, 28±18 vs 12±10 days; P=.005) and were more likely to have been treated with vancomycin (70% vs 10.3%; P=.001) than patients with vancomycin sensitive enterococcal bacteremia. The mortality (41.0%) associated with enterococcal bacteremia was similar to the overall bacteremic mortality (41.7%). There was no difference in episode-specific mortality associated with vancomycin-resistant enterococci (40%) vs vancomycin-sensitive enterococci (38.7%). Of the 4 deaths associated with vancomycin-resistant enterococcal bacteremia, only 2 occurred within 14 days of the bacteremia, as did 8 of 12 deaths associated with vancomycin sensitive enterococcal bacteremia (P=.64). Conclusions: Enterococci were the most commonly isolated nosocomial blood-borne pathogens in the surgical intensive care unit. Nearly 25% of the enterococcal bacteremic episodes were resistant to vancomycin. Vancomycin-resistant Enterococcus is associated with a prolonged hospital stay and with vancomycin use. Nevertheless, vancomycin resistance itself does not increase the mortality rate associated with enterococcal bacteremia.
AB - Objective: To determine the incidence and mortality rate associated with nosocomial bacteremia caused by vancomycin-resistant Enterococcus in a surgical intensive care unit. Design: A retrospective study. Setting: The surgical intensive care unit of a large university hospital tertiary referral center. Patients: All patients in the surgical intensive care unit with a documented nosocomial bacteremia between January 1, 1992, and December 31, 1994. Interventions: None. Main Outcome Measure: Mortality rate. Results: Of the 134 nosocomial bacteremic episodes, 30.6% involved enterococci; 24.4% of the enterococci were resistant to vancomycin. Patients with vancomycin-resistant enterococcal bacteremia had a significantly longer hospital stay (mean±SD, 28±18 vs 12±10 days; P=.005) and were more likely to have been treated with vancomycin (70% vs 10.3%; P=.001) than patients with vancomycin sensitive enterococcal bacteremia. The mortality (41.0%) associated with enterococcal bacteremia was similar to the overall bacteremic mortality (41.7%). There was no difference in episode-specific mortality associated with vancomycin-resistant enterococci (40%) vs vancomycin-sensitive enterococci (38.7%). Of the 4 deaths associated with vancomycin-resistant enterococcal bacteremia, only 2 occurred within 14 days of the bacteremia, as did 8 of 12 deaths associated with vancomycin sensitive enterococcal bacteremia (P=.64). Conclusions: Enterococci were the most commonly isolated nosocomial blood-borne pathogens in the surgical intensive care unit. Nearly 25% of the enterococcal bacteremic episodes were resistant to vancomycin. Vancomycin-resistant Enterococcus is associated with a prolonged hospital stay and with vancomycin use. Nevertheless, vancomycin resistance itself does not increase the mortality rate associated with enterococcal bacteremia.
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U2 - 10.1001/archsurg.1997.01430250078017
DO - 10.1001/archsurg.1997.01430250078017
M3 - Article
C2 - 9006556
AN - SCOPUS:0031032132
SN - 0004-0010
VL - 132
SP - 76
EP - 81
JO - Archives of surgery
JF - Archives of surgery
IS - 1
ER -