Enteric neural crest-derived cells and neural stem cells

Biology and therapeutic potential

A. J. Burns, Pankaj Jay Pasricha, H. M. Young

Research output: Contribution to journalArticle

Abstract

The enteric nervous system arises from two regions of the neural crest; the vagal neural crest which gives rise to the vast majority of enteric neurones throughout the gastrointestinal tract, and the sacral neural crest which contributes a smaller number of cells that are mainly distributed within the hindgut. The migration of vagal neural crest cells into, and along the gut is promoted by GDNF, which is expressed by the gut mesenchyme and is the ligand for the Ret/GFRα1 signalling complex present on migrating vagal-derived crest cells. Sacral neural crest cells enter the gut after it has been colonized by vagal neural crest cells, but the molecular control of sacral neural crest cell development has yet to be elucidated. Under the influence of both intrinsic and extrinsic cues, neural crest cells differentiate into glia and different types of enteric neurones at different developmental stages. Recently, the potential for neural stem cells to form an enteric nervous system has been examined, with the ultimate aim of using neural stem cells as a therapeutic strategy for some gut disorders where enteric neurones are reduced or absent.

Original languageEnglish (US)
Pages (from-to)3-7
Number of pages5
JournalNeurogastroenterology and Motility
Volume16
Issue numberSUPPL. 1
StatePublished - Apr 2004
Externally publishedYes

Fingerprint

Neural Stem Cells
Neural Crest
Cell Biology
Enteric Nervous System
Therapeutics
Neurons
Glial Cell Line-Derived Neurotrophic Factor
Mesoderm
Neuroglia
Cues
Gastrointestinal Tract
Cell Count
Ligands

Keywords

  • Development
  • Enteric nervous system
  • Gut
  • Neural crest cells
  • Neural stem cells

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology
  • Neuroscience(all)

Cite this

Enteric neural crest-derived cells and neural stem cells : Biology and therapeutic potential. / Burns, A. J.; Pasricha, Pankaj Jay; Young, H. M.

In: Neurogastroenterology and Motility, Vol. 16, No. SUPPL. 1, 04.2004, p. 3-7.

Research output: Contribution to journalArticle

@article{4d174badeae24b83bf4e8528e9745c6c,
title = "Enteric neural crest-derived cells and neural stem cells: Biology and therapeutic potential",
abstract = "The enteric nervous system arises from two regions of the neural crest; the vagal neural crest which gives rise to the vast majority of enteric neurones throughout the gastrointestinal tract, and the sacral neural crest which contributes a smaller number of cells that are mainly distributed within the hindgut. The migration of vagal neural crest cells into, and along the gut is promoted by GDNF, which is expressed by the gut mesenchyme and is the ligand for the Ret/GFRα1 signalling complex present on migrating vagal-derived crest cells. Sacral neural crest cells enter the gut after it has been colonized by vagal neural crest cells, but the molecular control of sacral neural crest cell development has yet to be elucidated. Under the influence of both intrinsic and extrinsic cues, neural crest cells differentiate into glia and different types of enteric neurones at different developmental stages. Recently, the potential for neural stem cells to form an enteric nervous system has been examined, with the ultimate aim of using neural stem cells as a therapeutic strategy for some gut disorders where enteric neurones are reduced or absent.",
keywords = "Development, Enteric nervous system, Gut, Neural crest cells, Neural stem cells",
author = "Burns, {A. J.} and Pasricha, {Pankaj Jay} and Young, {H. M.}",
year = "2004",
month = "4",
language = "English (US)",
volume = "16",
pages = "3--7",
journal = "Neurogastroenterology and Motility",
issn = "1350-1925",
publisher = "Wiley-Blackwell",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Enteric neural crest-derived cells and neural stem cells

T2 - Biology and therapeutic potential

AU - Burns, A. J.

AU - Pasricha, Pankaj Jay

AU - Young, H. M.

PY - 2004/4

Y1 - 2004/4

N2 - The enteric nervous system arises from two regions of the neural crest; the vagal neural crest which gives rise to the vast majority of enteric neurones throughout the gastrointestinal tract, and the sacral neural crest which contributes a smaller number of cells that are mainly distributed within the hindgut. The migration of vagal neural crest cells into, and along the gut is promoted by GDNF, which is expressed by the gut mesenchyme and is the ligand for the Ret/GFRα1 signalling complex present on migrating vagal-derived crest cells. Sacral neural crest cells enter the gut after it has been colonized by vagal neural crest cells, but the molecular control of sacral neural crest cell development has yet to be elucidated. Under the influence of both intrinsic and extrinsic cues, neural crest cells differentiate into glia and different types of enteric neurones at different developmental stages. Recently, the potential for neural stem cells to form an enteric nervous system has been examined, with the ultimate aim of using neural stem cells as a therapeutic strategy for some gut disorders where enteric neurones are reduced or absent.

AB - The enteric nervous system arises from two regions of the neural crest; the vagal neural crest which gives rise to the vast majority of enteric neurones throughout the gastrointestinal tract, and the sacral neural crest which contributes a smaller number of cells that are mainly distributed within the hindgut. The migration of vagal neural crest cells into, and along the gut is promoted by GDNF, which is expressed by the gut mesenchyme and is the ligand for the Ret/GFRα1 signalling complex present on migrating vagal-derived crest cells. Sacral neural crest cells enter the gut after it has been colonized by vagal neural crest cells, but the molecular control of sacral neural crest cell development has yet to be elucidated. Under the influence of both intrinsic and extrinsic cues, neural crest cells differentiate into glia and different types of enteric neurones at different developmental stages. Recently, the potential for neural stem cells to form an enteric nervous system has been examined, with the ultimate aim of using neural stem cells as a therapeutic strategy for some gut disorders where enteric neurones are reduced or absent.

KW - Development

KW - Enteric nervous system

KW - Gut

KW - Neural crest cells

KW - Neural stem cells

UR - http://www.scopus.com/inward/record.url?scp=2342520620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2342520620&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 3

EP - 7

JO - Neurogastroenterology and Motility

JF - Neurogastroenterology and Motility

SN - 1350-1925

IS - SUPPL. 1

ER -