Enteric bacterial toxins: Mechanisms of action and linkage to intestinal secretion

Cynthia Louise Sears, James B. Kaper

Research output: Contribution to journalArticle

Abstract

A wide range of bacteria have been implicated as potential etiologies of diarrheal disease. Many of these organisms have been reported to produce one or more toxins postulated as important in the pathogenesis of the diarrhea resulting from infection with the organism. The primary goal of this review is to critically assess the linkage between the mechanism of action of toxins produced by human enteric pathogens and the stimulation of intestinal secretion. To accomplish this goal, the range of criteria used to demonstrate pathogenicity of an enteric bacterial toxin and potential mechanisms stimulating net intestinal secretion are reviewed. A detailed description of each enteric toxin is presented, and revised criteria are proposed for classification of enteric bacterial toxins. Throughout this review, emphasis has been given to data derived from studies of toxins in potentially relevant models of disease, namely intestinal mucosa in vivo and/or intestinal epithelial cells in vitro.

Original languageEnglish (US)
Pages (from-to)167-215
Number of pages49
JournalMicrobiological Reviews
Volume60
Issue number1
StatePublished - Mar 1996

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Intestinal Secretions
Bacterial Toxins
Intestinal Mucosa
Virulence
Diarrhea
Epithelial Cells
Bacteria
Infection
In Vitro Techniques

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology

Cite this

Enteric bacterial toxins : Mechanisms of action and linkage to intestinal secretion. / Sears, Cynthia Louise; Kaper, James B.

In: Microbiological Reviews, Vol. 60, No. 1, 03.1996, p. 167-215.

Research output: Contribution to journalArticle

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