Entanglement-Based Thermoplastic Shape Memory Polymeric Particles with Photothermal Actuation for Biomedical Applications

Qiongyu Guo, Corey J. Bishop, Randall A. Meyer, David R. Wilson, Lauren Olasov, Daphne E. Schlesinger, Patrick T. Mather, James B. Spicer, Jennifer Hartt Elisseeff, Jordan Green

Research output: Contribution to journalArticle

Abstract

Triggering shape-memory functionality under clinical hyperthermia temperatures could enable the control and actuation of shape-memory systems in clinical practice. For this purpose, we developed light-inducible shape-memory microparticles composed of a poly(d,l-lactic acid) (PDLLA) matrix encapsulating gold nanoparticles (Au@PDLLA hybrid microparticles). This shape-memory polymeric system for the first time demonstrates the capability of maintaining an anisotropic shape at body temperature with triggered shape-memory effect back to a spherical shape at a narrow temperature range above body temperature with a proper shape recovery speed (37 < T < 45 °C). We applied a modified film-stretching processing method with carefully controlled stretching temperature to enable shape memory and anisotropy in these micron-sized particles. Accordingly, we achieved purely entanglement-based shape-memory response without chemical cross-links in the miniaturized shape-memory system. Furthermore, these shape-memory microparticles exhibited light-induced spatiotemporal control of their shape recovery using a laser to trigger the photothermal heating of doped gold nanoparticles. This shape-memory system is composed of biocompatible components and exhibits spatiotemporal controllability of its properties, demonstrating a potential for various biomedical applications, such as tuning macrophage phagocytosis as demonstrated in this study.

Original languageEnglish (US)
Pages (from-to)13333-13341
Number of pages9
JournalACS Applied Materials and Interfaces
Volume10
Issue number16
DOIs
StatePublished - Apr 25 2018

Keywords

  • anisotropy
  • gold
  • nanoparticle
  • photothermal
  • polymer
  • shape
  • shape memory
  • thermoplastic

ASJC Scopus subject areas

  • Materials Science(all)

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