Entamoeba histolytica causes intestinal secretion: Role of serotonin

Katherine McGowan, Ann Kane, Nancy Asarkof, Joan Wicks, Victoria Guerina, John Kellum, Sherri Baron, Alan R. Gintzler, Mark Donowitz

Research output: Contribution to journalArticlepeer-review


Lysates of the protozoan parasite Entamoeba histolytica altered active electrolyte transport when present on the serosal surface of rabbit ileum and rat colon. The lysate-induced effects on electrolyte transport were similar to those caused by serotonin, and were blocked by bufotenine, an analog known to inhibit the action of serotonin. The transport effects were partially inhibited by antibody to serotonin. The amebic lysates were shown to contain serotonin by radioimmunoassay, high-performance liquid chromatography, and thin-layer chromatography. These results suggest that the serotonin present in Entamoeba histolytica may be important in the diarrhea seen in amebiasis.

Original languageEnglish (US)
Pages (from-to)762-764
Number of pages3
Issue number4612
StatePublished - Jan 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • General

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