Entamoeba histolytica-associated diarrheal illness is negatively associated with the growth of preschool children: evidence from a prospective study

Dinesh Mondal, William A. Petri, R. Bradley Sack, Beth D. Kirkpatrick, Rashidul Haque

Research output: Contribution to journalArticle

Abstract

The enteric protozoa, Cryptosporidium, Giardia and Entamoeba histolytica, cause diarrhea in children. We investigated the association of enteric protozoan-associated diarrheal illness with the nutritional status and growth of preschool children in Dhaka, Bangladesh. The subjects were 221 children aged 2-5 years who were followed prospectively for diarrheal illness for 3 years. The weight and height of the children were measured at entry and at 4-month intervals. Cryptosporidium and E. histolytica were diagnosed with commercially available stool antigen detection kits. Giardia was diagnosed by conventional microscopy. Cryptosporidium- and Giardia-associated diarrheal illness was not associated with the growth of the children. Children with E. histolytica-associated diarrheal illness had lower weight for age Z-score changes (-0.103 ± 0.120 vs. 0.176 ± 0.052, P = 0.038). Similarly, the change in height for age Z-score was lower in children with E. histolytica-associated diarrheal illness (-0.348 ± 0.186 vs. 0.142 ± 0.08, P = 0.018). Children with E. histolytica-associated diarrheal illness were 2.93 times (95% CI 1.01-8.52, P = 0.047) more likely to be malnourished and 4.69 times (95% CI 1.55-14.18, P = 0.006) more prone to be stunted. Entamoeba histolytica-associated diarrheal illness was negatively associated with the growth of preschool children.

Original languageEnglish (US)
Pages (from-to)1032-1038
Number of pages7
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume100
Issue number11
DOIs
StatePublished - Nov 1 2006

Keywords

  • Amebiasis
  • Bangladesh
  • Children
  • Diarrhea
  • Entamoeba histolytica
  • Nutritional status

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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