Enhancing retention and efficacy of cardiosphere-derived cells administered after myocardial infarction using a hyaluronan-gelatin hydrogel

Rachel R uckdeschel Smith, Eduardo Marbán, Linda Marbán

Research output: Contribution to journalArticle

Abstract

Cardiosphere-derived cells (CDCs) are under clinical development and are currently being tested in a clinical trial enrolling patients who have undergone a myocardial infarction. CDCs are presently administered via infusion into the infarct-related artery and have been shown in early clinical trials to be effective agents of myocardial regeneration. This review describes the administration of CDCs in a hyaluronan-gelatin hydrogel via myocardial injection and the subsequent improvements in therapeutic benefit seen in animal models. Development of a next generation therapy involving the combination of CDCs and hydrogel is discussed.

Original languageEnglish (US)
JournalBiomatter
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Keywords

  • ALLSTAR trial
  • CADUCEUS trial
  • cardiosphere-derived cells
  • hyaluronan-gelatin hydrogel
  • myocardial infarction

ASJC Scopus subject areas

  • Medicine(all)

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