TY - JOUR
T1 - Enhancing recruitment and retention of minority populations for clinical research in pulmonary, critical care, and sleep medicine an official american thoracic society research statement
AU - Thakur, Neeta
AU - Holguin, Fernando
AU - Alvidrez, Jennifer
AU - Abdulai, Raolat
AU - Appell, Donna
AU - Araojo, Richardae
AU - Bime, Christian
AU - Burchard, Esteban G.
AU - Castro, Lauren
AU - Celedon, Juan C.
AU - Ferreira, Juliana
AU - Ford, Marvella E.
AU - George, Maureen
AU - Graham, Leroy
AU - Hendrickson, Carolyn
AU - Kiley, James P.
AU - Lovinsky-Desir, Stephanie
AU - Mageto, Yolanda
AU - Mainous, Arch G.
AU - Pakhale, Smita
AU - Reese, Rodney
AU - Riekert, Kristin A.
AU - Roman, Jesse
AU - Ruvalcaba, Elizabeth
AU - Sharma, Sunil
AU - Shete, Priya
AU - Spitzer, Ginger
AU - Wisnivesky, Juan P.
N1 - Publisher Copyright:
Copyright © 2021 by the American Thoracic Society.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Background: Well-designed clinical research needs to obtain information that is applicable to the general population. However, most current studies fail to include substantial cohorts of racial/ ethnic minority populations. Such underrepresentation may lead to delayed diagnosis or misdiagnosis of disease, wide application of approved interventions without appropriate knowledge of their usefulness in certain populations, and development of recommendations that are not broadly applicable. Goals: To develop best practices for recruitment and retention of racial/ethnic minorities for clinical research in pulmonary, critical care, and sleep medicine. Methods: The American Thoracic Society convened a workshop in May of 2019. This included an international interprofessional group from academia, industry, the NIH, and the U.S. Food and Drug Administration, with expertise ranging from clinical and biomedical research to community-based participatory research methods and patient advocacy. Workshop participants addressed historical and current mistrust of scientific research, systemic bias, and social and structural barriers to minority participation in clinical research. A literature search of PubMed and Google Scholar was performed to support conclusions. The search was not a systematic review of the literature. Results: Barriers at the individual, interpersonal, institutional, and federal/policy levels were identified as limiting to minority participation in clinical research. Through the use of a multilevel framework, workshop participants proposed evidence-based solutions to the identified barriers. Conclusions: To date, minority participation in clinical research is not representative of the U.S. and global populations. This American Thoracic Society research statement identifies potential evidence-based solutions by applying a multilevel framework that is anchored in community engagement methods and patient advocacy.
AB - Background: Well-designed clinical research needs to obtain information that is applicable to the general population. However, most current studies fail to include substantial cohorts of racial/ ethnic minority populations. Such underrepresentation may lead to delayed diagnosis or misdiagnosis of disease, wide application of approved interventions without appropriate knowledge of their usefulness in certain populations, and development of recommendations that are not broadly applicable. Goals: To develop best practices for recruitment and retention of racial/ethnic minorities for clinical research in pulmonary, critical care, and sleep medicine. Methods: The American Thoracic Society convened a workshop in May of 2019. This included an international interprofessional group from academia, industry, the NIH, and the U.S. Food and Drug Administration, with expertise ranging from clinical and biomedical research to community-based participatory research methods and patient advocacy. Workshop participants addressed historical and current mistrust of scientific research, systemic bias, and social and structural barriers to minority participation in clinical research. A literature search of PubMed and Google Scholar was performed to support conclusions. The search was not a systematic review of the literature. Results: Barriers at the individual, interpersonal, institutional, and federal/policy levels were identified as limiting to minority participation in clinical research. Through the use of a multilevel framework, workshop participants proposed evidence-based solutions to the identified barriers. Conclusions: To date, minority participation in clinical research is not representative of the U.S. and global populations. This American Thoracic Society research statement identifies potential evidence-based solutions by applying a multilevel framework that is anchored in community engagement methods and patient advocacy.
KW - Clinical research
KW - Health disparities
KW - Minorities
KW - Recruitment
KW - Retention
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U2 - 10.1164/rccm.202105-1210ST
DO - 10.1164/rccm.202105-1210ST
M3 - Review article
C2 - 34347574
AN - SCOPUS:85112234813
SN - 1073-449X
VL - 204
SP - E26-E50
JO - American journal of respiratory and critical care medicine
JF - American journal of respiratory and critical care medicine
IS - 3
ER -