Enhancer-site downstream binding protein activity is enriched in rat tissues that express the class I alcohol dehydrogenase gene

Research output: Contribution to journalArticlepeer-review

Abstract

The activity of the rat class I alcohol dehydrogenase (ADH) is enriched in certain tissues including the liver, intestine and testis. The tissue-specific expression of the gene encoding ADH in the rat was studied and found to closely correlate with tissue isozymic activity. A factor designated enhancer-site downstream binding protein (EDBP) was recently identified in the rat liver and found to interact with the proximal promoter of the class I ADH gene. The distribution of EDBP in nuclear extracts obtained from various tissues was examined based on its sequence-specific DNA binding property and found to correlate with tissue ADH expression. These findings suggest that EDBP is potentially a positive regulatory factor which is involved in controlling the tissue-specific expression of the ADH gene.

Original languageEnglish (US)
Pages (from-to)684-689
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume188
Issue number2
DOIs
StatePublished - Oct 30 1992

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Enhancer-site downstream binding protein activity is enriched in rat tissues that express the class I alcohol dehydrogenase gene'. Together they form a unique fingerprint.

Cite this