Enhancement of the Shaker B Δ6-46 current by fatty acids depends on the activation of the lipoxygenase metabolic pathway

Saïd Bendahhou, William S. Agnew

Research output: Contribution to journalArticlepeer-review

Abstract

Voltage-gated K+ channels are modulated by extracellular free unsaturated fatty acids. Both increases and attenuations of K+ channel activities have been observed. We studied the effect of cis-unsaturated fatty acids on Shaker B Δ6-46 and the endogenous outward rectifier K+ channels expressed in COS cell line, using the whole cell recording technique. For both K+ channels, exogenously applied unsaturated fatty acids dramatically increased the outward K+ currents. This enhancement was not mediated by cylooxygenase or epoxygenase (P450) enzymes. However, nordihydroguaiaretic acid, a lipoxygenase metabolic pathway blocker, did prevent the arachidonic acid-induced Shaker current enhancement.

Original languageEnglish (US)
Pages (from-to)1091-1093
Number of pages3
JournalPflugers Archiv European Journal of Physiology
Volume432
Issue number6
DOIs
StatePublished - 1996

Keywords

  • Arachidonic acid
  • Ischemia
  • Patch clamp
  • Potassium channels

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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